Results 91 to 100 of about 1,645,533 (278)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Attitude of broiler breeders toward the production of antibiotics-free chickens (case study: Tehran province) [PDF]

Bihdāsht-i Mavādd-i Ghaz̠āyī, 2016
: This research aimed to investigate the attitude of broiler breeders toward the production of antibiotics-free chickens in Tehran province. The statistical population in this study included all broiler breeders (N=450) in Tehran province.
A Behrouzi, S Mashayekhi, Gh Asgari Jafarabadi   +2 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Forecasting egg production performance and fluctuations in commercial free-range poultry systems using a random forest model

Smart Agricultural Technology
The free-range poultry industry is faced with numerous challenges that contribute significantly to the flock’s variability in egg production.
Yusuf Adewale Adejola, Terence Zimazile Sibanda, Isabelle Ruhnke, Johan Boshoff, Saluna Pokhrel, Mitchell Welch   +5 more
doaj   +1 more source

A Weighted Weak Law of Large Numbers for Free Random Variables [PDF]

We examine various conditions under which a weighted weak law of large numbers holds, in the context of noncommutative probability theory.Weak law of large numbers, Noncommutative probability ...
George Stoica, Raluca Balan
core  

Combinatorial aspects of weighted free Poisson random variables

Infinite Dimensional Analysis, Quantum Probability and Related Topics
This paper will be devoted to the study of weighted (deformed) free Poisson random variables from the viewpoint of orthogonal polynomials and statistics of non-crossing partitions. A family of weighted (deformed) free Poisson random variables will be defined in a sense by the sum of weighted (deformed) free creation, annihilation, scalar, and ...
Nobuhiro Asai, Hiroaki Yoshida
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Set of Master Variables for the Two-Star Random Graph

Entropy
The two-star random graph is the simplest exponential random graph model with nontrivial interactions between the graph edges. We propose a set of auxiliary variables that control the thermodynamic limit where the number of vertices N tends to infinity ...
Pawat Akara-pipattana, Oleg Evnin
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Early Prediction of Regional Red Needle Cast Outbreaks Using Climatic Data Trends and Satellite-Derived Observations

Remote Sensing
Red needle cast (RNC), mainly caused by Phytophthora pluvialis, is a very damaging disease of the widely grown species radiata pine within New Zealand.
Michael S. Watt, Andrew Holdaway, Pete Watt, Grant D. Pearse, Melanie E. Palmer, Benjamin S. C. Steer, Nicolò Camarretta, Emily McLay, Stuart Fraser   +8 more
doaj   +1 more source