Results 81 to 90 of about 2,007,881 (314)

Organs in Color: Utilizing Free Software and Emerging Multi Jet Fusion Technology to Color and Surface Label 3D-Printed Anatomical Models. [PDF]

J Digit Imaging, 2022
Rehman M, Arsenault L, Javan R.
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Following the Open-Source Trail Outside the Digital World: The Case of Open-Source Seeds

tripleC: Communication, Capitalism & Critique, 2016
In this article, we assess the application of the open-source development model in the field of agricultural research and development, as a potential tool for upholding both public scientific research, and farmer-led innovation and farmers’ rights. First,
Elsa Tsioumani, Mike Muzurakis, Yannis Ieropoulos, Asterios Tsioumanis   +3 more
doaj   +1 more source

'SleepCycles' package for R - A free software tool for the detection of sleep cycles from sleep staging. [PDF]

MethodsX, 2021
Blume C, Cajochen C.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

INSPECTOR: free software for magnetic resonance spectroscopy data inspection, processing, simulation and analysis. [PDF]

Sci Rep, 2021
Gajdošík M, Landheer K, Swanberg KM, Juchem C.   +3 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

"Free Software, Free Society"?

, 2013
Freie Software wird von Communities entwickelt und verbreitet. Die hier aktiven Personen wollen sich und andere in die Lage versetzen, technische Artefakte selbst mitzugestalten, statt sie als gegeben hinzunehmen. Sie streben zudem einen besonders offenen Umgang mit Wissen an.
openaire   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Development of track log and point of interest management system using Free and Open Source Software [PDF]

, 2010
Daisuke Yoshida, Xianfeng Song, Venkatesh Raghavan   +2 more
openalex   +1 more source