Results 91 to 100 of about 5,543,577 (334)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Multimode Collective Atomic Recoil Lasing in Free Space

Atoms, 2020
Cold atomic clouds in collective atomic recoil lasing are usually confined by an optical cavity, which forces the light-scattering to befall in the mode fixed by the resonator.
Angel T. Gisbert, Nicola Piovella
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Reciprocating propagation of laser pulse intensity in free space [PDF]

, 2021
Zhaoyang Li, Y. J. Gu, Junji Kawanaka
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Free space method using a vector network analyzer to determine the dielectric permittivity of materials in microwave range

Doklady Belorusskogo gosudarstvennogo universiteta informatiki i radioèlektroniki, 2019
Modified free space method using a vector network analyzer is proposed. The algorithm for determining the dielectric constant is developed. The results of measurements of the amplitude and phase of the reflection coefficient and transmission coefficient ...
N. A. Pevneva, A. L. Gurskii, A. M. Kostrikin   +2 more
doaj  

Studying free-space transmission statistics and improving free-space quantum key distribution in the turbulent atmosphere

New Journal of Physics, 2012
The statistical fluctuations in free-space links in the turbulent atmosphere are important for the distribution of quantum signals. To that end, we first study statistics generated by the turbulent atmosphere in an entanglement-based free-space quantum ...
C Erven, B Heim, E Meyer-Scott, J P Bourgoin, R Laflamme, G Weihs, T Jennewein   +6 more
doaj   +1 more source

Analysis of Free-Space Optics Development

Metrology and Measurement Systems, 2017
The article presents state of work in technology of free-space optical communications (Free Space Optics − FSO). Both commercially available optical data links and their further development are described.
Mikołajczyk Janusz, Bielecki Zbigniew, Bugajski Maciej, Piotrowski Józef, Wojtas Jacek, Gawron Waldemar, Szabra Dariusz, Prokopiuk Artur   +7 more
doaj   +1 more source

Cosets of Free Field Algebras via Arc Spaces [PDF]

, 2023
Andrew R. Linshaw, Bailin Song
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source