Results 101 to 110 of about 1,020,372 (262)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Free Space Optical Mesh Networks: A Survey

open access: yesIEEE Open Journal of the Communications Society
Free space optical (FSO) communication, known for its high data rates and immunity to electromagnetic interference, encounters challenges such as weather dependency, misalignment issues, and line-of-sight (LoS) requirements.
Ferdaous Tarhouni   +2 more
doaj   +1 more source

Few-Mode SDM Receivers Exploiting Parallelism of Free Space

open access: yesIEEE Photonics Journal, 2019
Few-mode receivers exploiting parallelism of free space for space-division multiplexed (SDM) transmission, in which one free-space 90° optical hybrid can be shared among multiple SDM channels, are proposed and experimentally demonstrated. A $\text{
Yongben Wang   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Configurable optical vortex ladder in free space

open access: yesAPL Photonics
Light eigenmodes with cylindrical symmetry, such as the Laguerre–Gaussian (LG) modes, are characterized by the radial and angular quantum numbers indicating radial nodes and orbital angular momentum (OAM), which are independent and invariant upon beam ...
Xinhao Fan   +9 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Free Space Optics: Current Applications and Future Challenges

open access: yesInternational Journal of Optics, 2015
FSO is a communication system where free space acts as medium between transceivers and they should be in LOS for successful transmission of optical signal. Medium can be air, outer space, or vacuum.
Aditi Malik, Preeti Singh
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

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