Results 71 to 80 of about 7,636,336 (303)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A high bit rate free space optics based ring topology having carrier‐less nodes

IET Communications, 2021
A free space optics based ring topology that transmits full‐duplex data to four different nodes in the ring is proposed. The link is designed such that the four nodes do not require a local optical source to transmit the uplink data.
Jawad Mirza, Waqas A. Imtiaz, Abdulah Jeza Aljohani, Salman Ghafoor   +3 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Bit error rate measurement of free space optical communication links under laboratory controlled conditions [PDF]

, 2011
This paper outlines the experimental investigation of the fog effect on the bit error rate (BER) performance of the free space optical (FSO) communication link under a controlled laboratory environment.
Ghassemlooy, Zabih, Gholami, Asghar, Rajbhandari, Sujan, Ijaz, Muhammad, Le Minh, Hoa, Perez Soler, Joaquin   +5 more
core  

Experimental investigation of the performance of different modulation techniques under controlled FSO turbulence channel [PDF]

, 2010
This paper experimentally investigates and compares the performance of the free space optics system employing three different modulation schemes, on-off keying (OOK) with nonreturn- to-zero (NRZ) and return-to-zero (RZ) and the binary phase shift keying (
Z. Ghassemlooy, Adebanjo, Olusegun, O. Adebanjo, S. Ansari, S. Rajbhandari, Ghassemlooy, Zabih, H. Le Minh, Ansari, S., A. Gholami, Rajbhandari, Sujan, Ijaz, Muhammad, M. Ijaz, Le Minh, Hoa   +12 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A low-cost man-portable free-space optics communication device for Ethernet applications [PDF]

, 2004
This thesis sought to design and implement a low-cost, portable, Free-Space Optics (FSO) communications device for Ethernet applications. Under some circumstances such a device would have utility at a Combat Operations Center (COC), a Field Artillery ...
Perera, Janaka P.
core   +2 more sources

The propagation of Hermite–Gauss wave packets in optics and quantum mechanics

Natural Sciences
The two‐dimensional paraxial equation of optics and the two‐dimensional time‐dependent Schrödinger equation, derived as approximations of the three‐dimensional Helmholtz equation and the three‐dimensional time‐independent Schrödinger equation ...
John S. Briggs
doaj   +1 more source

Diffractive optical computing in free space

Nature Communications
Abstract Structured optical materials create new computing paradigms using photons, with transformative impact on various fields, including machine learning, computer vision, imaging, telecommunications, and sensing. This Perspective sheds light on the potential of free-space optical systems based on engineered surfaces for advancing ...
Jingtian Hu, Deniz Mengu, Dimitrios C. Tzarouchis, Brian Edwards, Nader Engheta, Aydogan Ozcan   +5 more
openaire   +3 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source