Results 121 to 130 of about 9,437,217 (301)

Comparing Methods of Deforming and Overlapping Meshes to Simulate the Motion of Bodies on a Free Surface

Fluids
Two methods of accounting for the motion of the bodies—the deforming mesh method and the method of overlapping meshes (or overset mesh method)—are compared using problems with floating bodies, which are typical for the shipbuilding industry.
Andrey Kozelkov, Andrey Kurkin, Kseniya Plygunova, Vadim Kurulin, Vitaliy Gerasimov   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Free form surfaces

, 2000
A method to construct continuous order k surfaces of arbitrary topological type by tracing a mesh that represents a 2-manifold is presented. The presented approach constructs the surface from a collection of pieces which overlap, using the known technology of manifolds.
Cotrina Navau, Josep, Pla García, Núria   +1 more
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Improving the Dupuit-Forchheimer groundwater free surface approximation

, 2005
For steady two-dimensional free surface flow over a horizontal impervious base, the Dupuit-Forchheimer theory assumes that the vertical component of velocity is zero, even for non-zero accretion rate at the free surface.-This is improved by assuming that
Knight, John
core   +1 more source

NUMERICAL STUDY OF THE WATER SURFACE MOVEMENT DURING A DAM BREAK ON A REAL TERRAIN OF THE TASOTKEL RESERVOIR, ZHAMBYL REGION, KAZAKHSTAN

Scientific Journal of Astana IT University
This work presents a comprehensive numerical simulation of the dam-break process at the Tasotkel reservoir, located in real terrain conditions in the Zhambyl region.
Yeldos Zhandaulet, Daulet Abilkairov, Alexandr Neftissov, Ilyas Kazambayev, Marat Bayandin, Lalita Kirichenko   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Virtual Element Method for Saturated Unconfined Seepage Flow Analysis

工程科学与技术
ObjectiveLocal mesh modification is one of the important approaches for solving the saturated unconfined seepage model when the fixed mesh method is used.
JIANG Wei, YANG Ting, OUYANG Ye, WU Yi, CHENG Yong, ZHENG Hong   +5 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source