Results 111 to 120 of about 5,227,455 (294)

Free surface in Underworld

open access: yes, 2021
<strong> Free surface in geodynamics simulations </strong> Geodynamic simulations increasingly rely on models with a true free surface to investigate questions of tectonic deformation, mantle convection, and coupling of surface processes and lithosphere dynamics. Historically, most mantle convection simulations have been performed with free-
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Investigation of Keel Curvature Effect on the Hydrodynamic Characteristics of a V-Shaped Planing Surface

open access: yesInternational Journal of Maritime Technology, 2015
In this paper, three-dimensional two phase turbulent free surface flow is solved by an in-house code. The incompressible Reynolds average Navier-Stocks equations (RANS) with k-ε turbulence model are solved by the finite volume method in the non ...
Hashem Moradi   +2 more
doaj  

Review of the Near-Water Effect of Rotors in Cross-Media Vehicles

open access: yesDrones
Cross-media vehicles, which combine the advantages of airplanes and submarines, are capable of performing complex tasks in different media and have attracted significant interest in recent years.
Xingzhi Bai   +6 more
doaj   +1 more source

Amplification and Increased Duration of Earthquake Motion on Uneven Stress-Free Ground

open access: yes, 2006
When a flat stress-free surface (i.e., the ground in seismological applications) separating air from a isotropic, homogeneous or horizontally-layered, solid substratum is solicited by a SH plane body wave incident in the substratum, the response in the ...
Groby, Jean-Philippe, Wirgin, Armand
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Free Vibration Analysis of a Liquid in a Circular Cylindrical Rigid Tank Using the Hierarchical Finite Element Method

open access: yesLatin American Journal of Solids and Structures
A hierarchical finite element is developed for the free vibration analysis of a liquid in a rigid cylindrical tank with or without a free surface. It is a hierarchical quadrilateral element and has the advantage that the hierarchical mode number is ...
Sidi Mohammed Hamza Cherif   +1 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

New Analytical Formulae and Theorems for the Wave Resistance [PDF]

open access: yesУчёные записки Казанского университета: Серия Физико-математические науки, 2015
Wave resistance is an important characteristic of bodies floating on a free surface or moving under it. A significant number of works pioneered by Lord Kelvin (1887) have been devoted to determination of this characteristic.
D.V. Maklakov
doaj  

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