Results 111 to 120 of about 14,166,725 (308)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Bubble interactions and bursting behaviors near a free surface
The Physics of Fluids, 2019 Tong Li +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 2000 A method to construct continuous order k surfaces of arbitrary topological type by tracing a mesh that represents a 2-manifold is presented. The presented approach constructs the surface from a collection of pieces which overlap, using the known technology of manifolds.
Cotrina Navau, Josep +1 more
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Virtual Element Method for Saturated Unconfined Seepage Flow Analysis
工程科学与技术ObjectiveLocal mesh modification is one of the important approaches for solving the saturated unconfined seepage model when the fixed mesh method is used.
JIANG Wei +5 more
doaj
Rubber-like elasticity in laser-driven free surface flow of a Newtonian fluid. [PDF]
Proc Natl Acad Sci U S A, 2023 Kayanattil M +3 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Numerical Simulation of Three-Dimensional Free Surface Flows Using the K-BKZ-PSM Integral Constitutive Equation. [PDF]
Polymers (Basel), 2023 Bertoco J +3 more
europepmc +1 more source