Results 91 to 100 of about 5,227,455 (294)
Journal of Marine Science and Engineering, 2019 The numerical calculation was performed for the KRISO Container Ship (KCS) hull-propeller-rudder system with different freedom hull motion by employing the Reynolds-Averaged Navier-Stokes (RANS) method and adopting the overset grid.
Liang Li +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Confrontation Between Smoothed Particle Hydrodynamics and Unsteady Reynolds-averaged Navier–Stokes Methods for a Sinking Rigid Body [PDF]
Journal of Applied Fluid MechanicsIn this article, we present detailed numerical results concerning the hydrodynamic behavior of two distinct rigid bodies; a cylinder and a wedge; interacting with a free water surface.
A. Bel Hadj Taher +2 more
doaj +1 more source
Where surface physics and fluid dynamics meet: rupture of an amphiphile layer by fluid flow
, 2006 We investigate the fluctuating pattern created by a jet of fluid impingent upon an amphiphile-covered surface. This microscopically thin layer is initially covered with 50 $\mu$m floating particles so that the layer can be visualized.
Frisch U. +6 more
core +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The effects of barriers on supershear rupture
Geophysical Research Letters, 2016 A barrier may induce a supershear rupture transition in some cases, whereas it may prevent the further propagation of a supershear rupture in other cases.
Jiankuan Xu, Zhenguo Zhang, Xiaofei Chen
doaj +1 more source
Computational Fluid Dynamics Analysis of Cavitating Hydrofoils Near the Sea Surface in Supercritical Open Channel Flows [PDF]
Journal of Applied Fluid MechanicsAs a high-speed submerged body travels beneath the water surface, it induces deformation of the free surface and may generate cavitation due to local pressure reductions.
G. Taghinia, A. Esmaeili
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source