Results 81 to 90 of about 9,437,217 (301)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Geometric Controls on Cascading and Supershear Rupture Across a Wavy Strike-Slip Fault

Geosciences
Fault waviness can control whether earthquakes arrest, cascade, or transition to supershear rupture, yet its interaction with hypocentral position and free-surface proximity remains poorly constrained. We use three-dimensional spontaneous dynamic-rupture
Jiankuan Xu, Yang Xu
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Linear Free Surface of Steady and Unsteady Flow Theoretical Study

Tikrit Journal of Pure Science
This study investigates the relationship between the crucial cone point in limiting steady and unsteady simulation flows inside a simple two-dimensional, vertical sand column subjected to water withdrawal.
Suha Ibrahim AL-Ali, Nihad Jalal AL-Awsi
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Computational Fluid Dynamics Analysis and Validation with Field Test of 1 MW Hydropower Turbine System

Energies
This study analyzed and validated a 1 MW hydropower turbine system using computational fluid dynamics (CFD) in conjunction with field test data. The fluid domain of the hydropower system includes the runner blade, vane, duct, and both inflow and outflow ...
Ki-Ha Kim, Dong-Hyun Kim, Suk-Jin Hong, Sang-Myung Lee   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Simulation of Wall Turbulent Flow Near a Free-Surface

, 2000
The behaviour of turbulent flow close to a free--surface is an interesting topic in fluid dynamics and specifically in the field of naval hydrodynamics. Such situations are present both in the wake of a ship hull and in the juncture between the side wall
Di Mascio Andrea, Broglia Riccardo, Muscari Roberto   +2 more
core  

Modeling of Free Surface Flows with Elastic Bodies Interactions [PDF]

, 2008
In this paper, a series of new fluid and structure interactions test cases with strong free surface effects are presented and computations of such flows with the Particle Finite Element Method (PFEM) (Idelsohn, Oiiate, Del Pin and Calvo, 2006) are ...
Souto-Iglesias, A., Zamora Rodriguez, Ricardo, Oñate Ibáñez de Navarra, Eugenio, Zamora-Rodríguez, R., Souto Iglesias, Antonio, Oñate Ibáñez, Eugenio, Idelsohn Barg, Sergio Rodolfo, Idelsohn, Sergio, Martí, J.   +8 more
core   +1 more source