Results 61 to 70 of about 5,227,455 (294)
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Free Surface Analysis of Spillway Flow under Radial Gate by EFG-NE Method [PDF]
The element-free Galerkin method (EFG) and the natural element method (NEM) are two well know methods in the computational mechanics and meshless methods. In this paper, a computational scheme using a variable domain and a fixed domain is presented based
Seyyed Abdossamad Javanmard
doaj
Stepped spillway is hydraulic structure designed to dissipate the excess in kinetic energy at the downstream of dams and can reduce the size of stilling basin at the toe of the spillway or chute.
Bentalha Chakib, Habi Mohammed
doaj +1 more source
Dense embeddings of surface groups
We discuss dense embeddings of surface groups and fully residually free groups in topological groups. We show that a compact topological group contains a nonabelian dense free group of finite rank if and only if it contains a dense surface group.
Abert +11 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Optimization of Performance Characteristics of Magnetofluidic Seals for Wind Power Plants
The use of magnetofluidic seals are a promising direction in sealing rotating shafts of wind power plants. Magnetofluidic seals are characterized by high tightness, simplicity of the design, low losses by friction.
O. N. Labkovich, S. G. Pogirnitskaya
doaj +1 more source
Morphing surfaces for the control of boundary layer transition [PDF]
A structure configured to modify its surface morphology between a smooth state and a rough state in response to an applied stress. In demonstrated examples, a soft (PDMS) substrate is produced, and is pre-strained. A relatively stiff overlayer of a metal,
Bhattacharya, Kaushik +2 more
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Aiming at the current lack of analytical research concerning the cylindrical shell-flow field coupling vibration and sound radiation system under the influence of a free surface, this paper proposes an analytical method which solves the vibration ...
GUO Wenjie +3 more
doaj +1 more source

