Results 71 to 80 of about 2,218 (160)

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Correlation Between Free Thyroxine Levels and Mortality in Hypertensive Patients

Clinical and Applied Thrombosis/Hemostasis
Objective: To study the link between free thyroxine (FT4) levels and mortality in hypertensive patients. Methods: Utilizing data from the National Health and Nutrition Examination Survey performed in the United States from 2007 to 2012.
Zhuang Chen MS, Jing Feng MS, Quanxin Wang MS, Ling Zhu MS, Anzhong Yu MS, Shimin Liang MS, Jian Li MS, Shiliang Zhang MD, Feng Wu MD   +8 more
doaj   +1 more source

Functional immune profiling reveals CD4+ T cell dysregulation in coeliac disease

Immunology &Cell Biology, EarlyView.
The T cell momentum assay quantifies division, survival and activation decay to reveal intrinsic CD4+ programming defects marked by prolonged activation and impaired feedback control in coeliac disease. This scalable platform provides a functional screen for early T cell dysregulation across autoimmune and immune‐mediated diseases.
Anthony J Farchione, HoChan Cheon, David Vremec, Julika Neumann, Gwenny M Verstappen, Melinda Y Hardy, Mai B Margetts, Lauren J Howson, Lee M Henneken, Maureen Forde, Jason A Tye‐Din, Susanne Heinzel, Philip D Hodgkin, Vanessa L Bryant   +13 more
wiley   +1 more source

RECONSTRUCTION OF HYPOPHYSIAL-THYROID LINK OF REGULATION OF REPRODUCTIVE SYSTEM IN WOMEN WITH CHRONIC VIRAL HEPATITIS

Acta Biomedica Scientifica, 2012
The article presents the results of a study of levels of hormones of hypophysial-thyroid, system, in women with parenteral chronic viral hepatitis B and C in the light menstrua! disorders. We examined.
E. L. Chudinova, L. F. Sholokhov, L. I. Kolesnikova, B. A. Fedorov   +3 more
doaj  

Newborn Thyroid Screening

Proceedings of Singapore Healthcare, 2010
The availability of rapid and robust thyroid stimulating hormone (TSH) and free thyroxine (fT4) assays are important tools for newborn thyroid screening.
Clementine YF Yap MSc, DLM(ASCP), Tar Choon Aw FRCP (Edin), FRCPA   +1 more
doaj   +1 more source

Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study

Diabetes, Metabolic Syndrome and Obesity, 2020
Xiaomin Nie,* Yun Shen,* Xiaojing Ma, Yiting Xu, Yufei Wang, Jian Zhou, Yuqian Bao Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key ...
Nie X, Shen Y, Ma X, Xu Y, Wang Y, Zhou J, Bao Y   +6 more
doaj  

Phenotypic characteristics of paroxysmal dyskinesia in 25 cats

Journal of Small Animal Practice, EarlyView.
Objectives Paroxysmal dyskinesia has, to date, been reported only systematically in Sphynx cats. This study aims to describe paroxysmal dyskinesia in additional breeds. Materials and Methods The medical records of cats from multiple hospitals presenting with episodes consistent with paroxysmal dyskinesia between 2020 and 2025 were retrospectively ...
T. Liatis, C. Maeso, A. De Stefani, A. Pergande, T. Elvira, A. Suñol   +5 more
wiley   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

USEFULNESS OF FREE THYROXINE TO FREE TRIIODOTHYRONINE RATIO FOR DIAGNOSTICS OF VARIOUS TYPES OF HYPERTHYROIDISM

Zdravniški Vestnik, 2015
Background: Different types of hyperthyroidism are treated differently. The correct diagnosis enables the adequate treatment. Clinical experiences suggest that free thyroxine (fT4) to free triiodothyronine (fT3) ratio is different for different types of ...
Jernej Grmek, Simona Gaberšček, Ajda Biček, Katja Zaletel   +3 more
doaj  

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source