Results 141 to 150 of about 4,513,547 (298)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Effect of constant collision mean free time on the boundary layer of the active collisional warm plasma. [PDF]
Sci Rep, 2021 Khoram M, Masoudi SF.
europepmc +1 more source
The Properties of the Equity Premium and the Risk-Free Rate: An Investigation Across Time and Countries [PDF]
We examine the relationship between the equity premium and the risk-free rate over time for Group of Seven countries. We show the existence of subsample instabilities, cross-country differences, and examine whether a consumption-based CAPM model is able ...
Gianni De Nicoló, Fabio Canova
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Evaluering van rekenaarpakkette as hulpmiddel by die opstel van vraestelle by die technikon Vrystaat [PDF]
, 2001 ThesisLecturers at the Technikon Free State who participated in a survey felt that too much time was spent on compiling questionnaires and memoranda.
Potgieter, Pieter Henri
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 1985 Photograph showing Bill Moss, a long-time local political figure and member of the Columbus Board of Education, taken by photographer Allen Zak for publication in the Columbus Free Press newspaper, ca. 1990.
Columbus Free Press (Publisher); Allen Zak (Photographer);
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
How do college students use their free time? A latent profile analysis of leisure activities and substance use. [PDF]
Leis Sci, 2023 Chan WY +6 more
europepmc +1 more source
TIME-FREE CONTINUOUS PROCESSES [PDF]
Proceedings of the National Academy of Sciences, 1968 openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source