Results 121 to 130 of about 12,862,021 (286)
Free time, gender and the pandemic: An exploration of children's daily routines in the times of COVID-19 in Chile. [PDF]
Child Soc, 2022 Díaz R +3 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Are items actively removed from working memory during free time in children with developmental language disorder? [PDF]
Int J Lang Commun Disord, 2022 Larson C +3 more
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Journal of Philosophy, 2015 In this paper I defend two conclusions: that time travel journeys to the past are not undertaken freely and, more generally, that nobody is free between the earliest arrival time and the latest departure time of a time travel journey to the past. Time travel to the past destroys freedom on a global scale.
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
TIME-FREE CONTINUOUS PROCESSES [PDF]
Proceedings of the National Academy of Sciences, 1968 openaire +2 more sources
A CMOS Integrator-Based Clock-Free Time-to-Digital Converter for Home-Monitoring LiDAR Sensors. [PDF]
Sensors (Basel), 2022 He Y, Park SM.
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
THE ART OF LEADING FREE TIME. LEADERSHIP LESSONS IN RECREATION [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria EconomieFree time is a fundamental element in ensuring the balance between professional and personal life, being essential for both mental health and individual performance.
GUȚĂ EDUARD LEONARD
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