Results 91 to 100 of about 2,116,515 (307)

Application of a water-related environmental health epidemiological process : a guide for environmental health practitioners [PDF]

open access: yes, 2000
ThesisOne of the more suitable methodologies to follow to assess the impacts of environmental factors on the health of humans would be the epidemiological process.
Theron, Leana
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Application of ANN-based Streamflow Forecasting Model for Agricultural Water Management in the Awash River Basin, Ethiopia

open access: yes, 2011
Published ArticleThis paper presents the application of a long-term streamflow forecasting model developed using artificial neural networks at a stream gauging station in the Awash River Basin, Ethiopia. The gauging station is located above the headworks
Babel, Mukand Singh   +1 more
core  

Quality of drinking water sources in the Bloemfontein area of the Mangaung Metropolitan Municipality [PDF]

open access: yes, 2013
Thesis (M. Tech. (Environmental Health)) -- Central University of technology, Free State, 2013Introduction: Drinking water of poor quality can cause a variety of diseases and may even result in death.
Ratikane, Mosepeli
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Free-living protozoa in drinking water supplies: community composition and role as hosts for Legionella pneumophila

open access: yes, 2011
Free-living protozoa in drinking water supplies: community composition and role as hosts for Legionella pneumophila Free-living protozoa, which feed on bacteria, play an important role in the communities of microorganisms and invertebrates in drinking
Valster, R.M.
core  

Evaluation of the management practices of small-scale dairy farmers in the North-Eastern Free State [PDF]

open access: yes, 2000
ThesisThe study evaluated the management practices of small-scale dairy farmers in the NorthEastern Free State. The sampling area focused on small-scale dairy farmers in the former self-governing territory of Qwaqwa, as well as parts of the Harrismith,
Masiteng, Takisi Janki
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

A soil water model for two contrasting tillage systems

open access: yes, 1970
Techniques were developed to simulate the soil-plant environment as a semi-dynamic hydrologic system. Exponential expressions were found to give reasonable estimates of soil evaporation prior to corn plant emergence.
Lillard, James H., Shanholtz, Vernon O.
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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