Results 111 to 120 of about 2,116,515 (307)
Drivers and Management of Nutrient Overload in Dams: Insights from Roodeplaat Dam, South Africa
HydrologyAnthropogenic activities significantly threaten aquatic ecosystems, accelerating water quality deterioration through pollution, overexploitation, and habitat disturbance.
Samkele Siphelele Mnyango +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Hydrodynamic interaction of horizontal circular cylinders with a free-surface
, 1996 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The two-dimensional problem of hydrodynamic interaction of the horizontal circular cylinders with a free-surface is investigated both analytically and ...
Moyo, S, Moyo, Simiso
core
International Journal for Parasitology: Parasites and WildlifeIntracellular apicomplexan haemoparasites from the genus Hepatozoon Miller 1908 have been described from a wide range of vertebrate hosts, including wild carnivores in Africa.
Michelle van As +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
, 2023 Free-water imaging can predict and monitor dopamine system degeneration in people with Parkinson's disease. It can also enhance the sensitivity of traditional diffusion tensor imaging (DTI) metrics for indexing neurodegeneration. However, these tools are
Tien K Khoo (19255618) +16 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
An assessment of the human health risks posed by pathogens through various water types [PDF]
, 2003 ThesisThe aim of this study was to determine whether people exposed to the waters at various pOints of use in selected areas of the Mangaung Municipality, were indeed subjected to a probability of infection by the bacterial pathogen Salmonella as ...
Steyn, Maronel
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source