Results 121 to 130 of about 2,116,515 (307)

Effects of diffuse effluents from Botshabelo on the microbiological quality of water in the Modder River [PDF]

open access: yes, 1994
ThesisThe value of selected indicator micro-organisms for assessment of faecal pollution of water, as well as the distinction of faecal pollution of animal or human origin of pollution, has been investigated.
Jagals, Paul
core  

Combined effects of ciprofloxacin and microplastics on alpine spring water microbiota: evidence from glacier-fed microcosm experiments

open access: yesFrontiers in Microbiology
IntroductionEmerging contaminants such as microplastics (MPs) and antibiotics pose increasing environmental and public health risks due to their persistence and incomplete removal by wastewater treatment processes. MPs can act as vectors for antibiotics,
Domenica Mosca Angelucci   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Advancing smoke-free public spaces: the challenge of water-pipe in the Canadian context

open access: yes, 2018
Background and challenges to implementation Canada once led the way with smoke-free public spaces and as a result, most Canadians are protected from second-hand smoke through legislation at multiple levels of government.
Lesley James, Harsha Kasi Vishwanathan
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The Fate of Water at the Electrochemical Interfaces: Electrochemical Behavior of Free Water vs. Coordinating Water

open access: yes, 2018
The water reduction which produces hydrogen is one key reaction for electrochemical energy storage. While it has been widely studied in traditional aqueous electrolytes for water splitting (electrolyzers), it also plays an important role for batteries ...
Michael, Deschamps   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

SAMPL6 Octanol-Water Partition Coefficients from Alchemical Free Energy Calculations with MBIS Atomic Charges

open access: yes, 2019
In molecular modeling the description of the interactions between molecules forms the basis for a correct prediction of macroscopic observables. Here, we derive atomic charges from the implicitly polarized electron density of eleven molecules in the ...
Maximiliano, Riquelme   +1 more
core   +1 more source

Wastewater treatment plants as reservoirs for Vibrio species: an assessment of the Abuja wastewater treatment plant in Nigeria

open access: yesDiscover Water
The occurrence of pathogenic Vibrio species in wastewater treatment plant (WWTP) effluents and the effluent-receiving waters is a significant risk to human health and needs to be monitored appropriately.
Ini-Abasi Ikinwot Ibangha   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

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