Results 41 to 50 of about 1,946,305 (214)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Mathematical and numerical optimality of non-singular fractional approaches on free and forced linear oscillator

Nonlinear Engineering, 2020
The prediction of oscillators is usually employed in various industrial and technological problems; such as car shock absorbers, bungee jumping, earthquake-proof buildings, musical instruments, metronome and the process of hearing.
Ali Abro Kashif, Qureshi Sania, Atangana Abdon   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Tri‐axial compressive behavior of high‐water material for deep underground spaces

Deep Underground Science and Engineering
Attributed to its superior water‐to‐solid ratio and quick setting time, the high‐water material is widely adopted in underground spaces as a cost‐effective and environmentally friendly backfill material.
Honglin Liu, Yang Xia, Jianbiao Bai, Zhongzong Cao, Zizheng Zhang, Hongchao Zhao   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Enlarged perivascular spaces in the basal ganglia region are associated with white matter interstitial fluid content via deep medullary vein dysfunction

Frontiers in Human Neuroscience
ObjectiveTo investigate the effect of enlarged perivascular spaces in the basal ganglia (BG-EPVS) on interstitial fluid (ISF) content in white matter and to assess the mediating role of deep medullary vein (DMV) dysfunction in this relationship among ...
Haiyuan Lan, Xinjun Lei, Qingchun Wang, Lebing Wang, Kunwang Li   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Mitochondrial genomes of African pangolins and insights into evolutionary patterns and phylogeny of the family Manidae

BMC Genomics, 2017
Background This study used next generation sequencing to generate the mitogenomes of four African pangolin species; Temminck’s ground pangolin (Smutsia temminckii), giant ground pangolin (S.
Zelda du Toit, Morné du Plessis, Desiré L. Dalton, Raymond Jansen, J. Paul Grobler, Antoinette Kotzé   +5 more
doaj   +1 more source

Molecular characterisation and morphological description of two new species of Hepatozoon Miller, 1908 (Apicomplexa: Adeleorina: Hepatozoidae) infecting leukocytes of African leopards Panthera pardus pardus (L.)

Parasites & Vectors, 2020
Background The African leopard Panthera pardus pardus (L.) is currently listed as a vulnerable species on the IUCN (International Union for the Conservation of Nature) red list of threatened species due to ongoing population declines.
Michelle van As, Edward C. Netherlands, Nico J. Smit   +2 more
doaj   +1 more source