Results 91 to 100 of about 12,878,813 (328)
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Free Will and Compatibilism [PDF]
The author mounts a case against the libertarian and hard determinist's thesis that free will is impossible in a deterministic world. He charges incompatibilists with misconstruing ordinary 'free will' talk by overlaying common language with their own ...
Allan, Leslie
core
A Formal Sociologic Study of Free Will [PDF]
, 2013 We make a formal sociologic study of the concept of free will. By using the language of mathematics and logic, we define what we call everlasting societies.
Giuffrida, Giovanni, Zarba, Calogero G.
core
Epistemological Remarks on Libet’s Experiments on Free Will: Between Voluntarism and Will
Rivista Internazionale di Filosofia e Psicologia, 2015 Libet’s experimental setting has been criticized at length ever since its first appearance, under both methodological and empirical aspects. In this paper, the attention will be driven on a neglected underpinning theme which has not yet been investigated,
Giampaolo Ghilardi
doaj +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
The Free-Will Postulate in Quantum Mechanics [PDF]
, 2007 The so-called "free will axiom" is an essential ingredient in many discussions concerning hidden variables in quantum mechanics. In this paper we argue that "free will" can be defined in different ways.
Hooft, Gerard 't
core +2 more sources
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Response to Dennett on Free Will Skepticism
Rivista Internazionale di Filosofia e Psicologia, 2017 What is at stake in the debate between those, such as Sam Harris and me, who contend that we would lack free will on the supposition that we are causally determined agents, and those that defend the claim that we might then retain free will, such as ...
Derk Pereboom
doaj +1 more source