Results 121 to 130 of about 4,952,966 (312)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
FREE YOUR MIND: BUDDHISM, CAUSALITY, AND THE FREE WILL PROBLEM
Zygon, 2020 The problem of free will is associated with a specific and significant kind of control over our actions, which is understood primarily in the sense that we have the freedom to do otherwise or the capacity for self‐determination.
doaj +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Assessment of the challenges affecting the efficient and effective management of district hospitals in the Motheo district in the Free State province [PDF]
, 2014 Thesis (M. Tech. (Public Management)) -- Central University of Technology, free State, [2014]The primary aim of the proposed study is to investigate the technical problems affecting the efficiency and effectiveness of District Hospitals in the Free State
Toli, Moeketshi Hendrick
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
I will if you will : towards sustainable consumption
, 2012 Report is summarised in 'I will if you will : towards sustainable consumption : a summary'.The Sustainable Consumption Roundtable (Great Britain), a joint initiative between the National Consumer Council and the Sustainable Development Commission ...
Sustainable Consumption Roundtable (Great Britain)
core
Salvation, Grace and Free Will in Petrarch
, 2020 Il saggio prende in esame l'influenza del secolare dibattito filosofico e teologico sul libero arbitrio nell'opera di Petrarca. Dopo un'ampia ricognizione nei codici patristici e biblici della biblioteca petrarchesca, il saggio discute l'ideale di ...
GERI, Lorenzo
core
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source