Results 121 to 130 of about 17,880,075 (308)
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Columbus Free Press subscription letter
Form letter encouraging subscription to and financial support for the Columbus Free Press, dated January 1990 as the publication was celebrating its 20th anniversary. The Columbus Free Press began as a bi-weekly publication in Columbus, Ohio, in 1970.
Columbus Free Press (Publisher)
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Columbus Free Press distribution sheet
This calculation sheet from February 1989 lists the distribution numbers of the Columbus Free Press at different locations around Columbus, Ohio. The Columbus Free Press began as a bi-weekly publication in Columbus, Ohio, in 1970.
Columbus Free Press (Publisher)
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Beliefs about drunken sex and free will
Sex under the influence of alcohol raises difficult ethical questions that are closely related to basic issues of human autonomy. How do beliefs about free will relate to ethical attitudes about drunken sex?
Kodi B. Arfer
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Columbus Free Press subscription form
Order form encouraging recipients to renew their subscription to the Columbus Free Press. The Columbus Free Press began as a bi-weekly publication in Columbus, Ohio, in 1970.
Columbus Free Press (Publisher)
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Free Will or Not: Causality Preserved but Access to Motor Decisions Obscured [PDF]
Empirical studies having addressed the free-will issue suffer from controversial methodologies and interpretations. We present a new paradigm involving a synchronization task where the time interval to synchronize with is randomly within and without ...
Andrei Gorea +2 more
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