Results 81 to 90 of about 13,850,882 (338)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
From free will to ultimate freedom [PDF]
Belgrade Philosophical AnnualThis essay begins with a discussion of free will, and finally offers a more robust theory of ultimate freedom. My basic claim is that ultimate freedom is compatible with complete scientific explanation of human choice in terms of preference.
Lehrer Keith
doaj +1 more source
Free will as private determinism [PDF]
This article suggests that our sense of free will is formed when others react to our behavior with surprise, even though our private knowledge tells us our behavior was determined by our preferences.
Markovitch, J. S.
core
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
How I learned to stop worrying and love the alien hand syndrome [PDF]
Belgrade Philosophical AnnualWillusionists claim that science has proven free will to be an illusion. We propose a thought experiment that demonstrates how this view leads to an absurd conclusion: the term "free will" can no longer be applied differently to cases where agents ...
Levin Sergei, Farina Mirko
doaj +1 more source
I have inquired as to what sort of knowledge humans need to make justifiable claims regarding free will. I defended the thesis that humans do not have the sort of knowledge which would allow them to make such claims.
Zafer, Kılıç
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Jamesian Free Will, The Two-stage Model Of William James [PDF]
, 2010 Research into two-stage models of “free will” – first “free” random generation of alternative possibilities, followed by “willed” adequately determined decisions consistent with character, values, and desires – suggests that William James was in 1884 the
Doyle, Bob
core
, 1960 Chapter One begins with a brief survey of the main participants in the Free Will dispute. It is argued, in general terms, that the dispute between them - whether or not Determinism is inconsistent with moral responsibility - can be settled only by a ...
Bradley, Raymond
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