Results 81 to 90 of about 12,878,813 (328)

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

open access: yesFEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan   +10 more
wiley   +1 more source

Meaning, autonomy, symbolic causality, and free will [PDF]

open access: yes, 2018
As physical entities that translate symbols into physical actions, computers offer insights into the nature of meaning and agency. • Physical symbol systems, generically known as agents, link abstractions to material actions.
Abbott, Russ
core  

Free Parking or Free Markets [PDF]

open access: yes, 2018
Free Parking or Free Markets DONALD SHOUP It is no doubt ironic that the motorcar, superstar of the capitalist system, expects to live rent-free. W OLFGANG Z UCKERMAN C ITIES SHOULD CHARGE THE RIGHT PRICES FOR CURB PARKING because the wrong prices produce such bad results. Where curb parking is underpriced and overcrowded, a surprising share of cars on
openaire   +3 more sources

Free will

open access: yesThe Philosophers' Magazine, 2009
false ; 2016-03-16T16:38 ...
unknown ( host institution )   +1 more
openaire   +2 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

open access: yesFEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez   +3 more
wiley   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

open access: yesFEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring   +6 more
wiley   +1 more source

Manipulation Arguments and Libertarian Accounts of Free Will [PDF]

open access: yes, 2020
In response to the increasingly popular manipulation argument against compatibilism, some have argued that libertarian accounts of free will are vulnerable to parallel manipulation arguments, and thus manipulation is not uniquely problematic for ...
Cyr, Taylor W.
core  

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

open access: yesFEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke   +2 more
wiley   +1 more source

Free will, the self and the brain [PDF]

open access: yes, 2007
The free will problem is defined and three solutions are discussed: no-freedom theory, libertarianism, and compatibilism. Strict determinism is often assumed in arguing for libertarianism or no-freedom theory.
Gomes, Gilberto
core  

To free or not to free? [PDF]

open access: yesActa Crystallographica Section D Biological Crystallography, 2014
Alexandre Urzhumtsev   +1 more
openaire   +3 more sources

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