Results 71 to 80 of about 1,685,246 (308)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Shaping, Progress and the Future of the Security and Defence Policy of the European union and its Impact on the Process of Enlargement [PDF]
Bezbednosni Dijalozi, 2014 The goal of this paper is to be perceived the security and defense aspect of the European Union, and how these aspects will affect the future enlargement of the EU.
Katerina Veljanovska, Goran Shibakovski
doaj
Revista de Derecho Ambiental, 2017 The negotiation process of a regional instrument on access rights in Latin America and the Caribbean has included in its current draft a provision on access to jus-tice in environmental matters (Article 9).
Gabriela Burdiles, Leonardo Cofré
doaj +1 more source
, 2016 Plotinus’ famous treatise against the Gnostics (33), together with contemporary and thematically related treatises on Intelligible Beauty (31), on Number (34), and on Free Will and the Will of the One (39), can be seen as providing the essential ...
Butler, Edward P.
core
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Early Signaling Events Induced by Elicitors of Plant Defenses
Molecular Plant-Microbe Interactions, 2006 Plant pathogen attacks are perceived through pathogen-issued compounds or plant-derived molecules that elicit defense reactions. Despite the large variety of elicitors, general schemes for cellular elicitor signaling leading to plant resistance can be ...
Angela Garcia-Brugger +7 more
doaj +1 more source
Applying Copyright Abandonment in the Digital Age [PDF]
, 2010 Copyright law protects orphan and parented works equally--but it shouldn\u27t. Consequently, current law unnecessarily restrains public access to works that authors have not exercised dominion over for decades.
Turetzky, Matthew W.
core +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source