Results 61 to 70 of about 14,384,629 (290)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Religion, Progress, and Intellectual Freedom: John Stuart Mill, Abraham Kuyper, and the Shape of a Plural Society

open access: yesEidos. A Journal for Philosophy of Culture
John Stuart Mill’s On Liberty is typically regarded as the key defense of free discussion in nineteenth-century Europe, and thus it remains relevant to contemporary concerns about free speech.
Manfred Svensson
doaj   +1 more source

Libertarianism & Category-Mistake [PDF]

open access: yesIdeas y Valores, 2009
This paper offers a defense against two accusations according to which libertarianism incurs in a category-mistake. The philosophy of Gilbert Ryle will be used to explain the reasons which ground these accusations. Further, it will be shown why, although
Carlos G. Patarroyo G.
doaj  

Plant-Mediated Effects of Water Deficit on the Performance of Tetranychus evansi on Tomato Drought-Adapted Accessions

open access: yesFrontiers in Plant Science, 2018
Climate change is expected to increase drought periods and the performance and dispersal of some invasive species such as Tetranychus evansi, which has been reported to take advantage of the nutritional changes induced by water-shortage on the tomato ...
Miguel G. Ximénez-Embún   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Aquinas and the free will defense

open access: yes, 2002
The dissertation is divided into two parts. The first part constitutes a critique of the two most popular versions of the Free Will Defense to the problem of moral evil, one based on a neo-Molinist account of the relationship between providence and ...
Grant, W. Matthews
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

The Wise Person Rules the Stars: The Impact of Islamic Debates About Free Will on the Work of Albert the Great

open access: yesReligions
In the modern world, free will as it is understood in Christian traditions is a complicated and contested topic. These debates are often reflective of those Islamic scholars had in the early centuries of the faith.
Scott Edward Hendrix, Meghri Doumanian
doaj   +1 more source

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