Results 51 to 60 of about 349,729 (260)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Of Distributive Justice and Hellfire
TheoLogicaDefenses of God’s permission of evil by appeal to free will are alleged to have a value problem. Laura Ekstrom argues that free will does not obviously have a value which would outweigh or justify the disvalue associated with moral evil and its ...
James Dominic Rooney
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Role of Vitamin E in Counteracting Oxidative Stress in Poultry
The Journal of Poultry Science, 2014 Oxidative stress is defined as the imbalance between prooxidants and antioxidants (in favor of the pro-oxidants). Reactive oxygen species (ROS) are produced in the body continuously as a part of normal metabolism.
Arun K. Panda, Gita Cherian
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Shaping, Progress and the Future of the Security and Defence Policy of the European union and its Impact on the Process of Enlargement [PDF]
Bezbednosni Dijalozi, 2014 The goal of this paper is to be perceived the security and defense aspect of the European Union, and how these aspects will affect the future enlargement of the EU.
Katerina Veljanovska, Goran Shibakovski
doaj
Revista de Derecho Ambiental, 2017 The negotiation process of a regional instrument on access rights in Latin America and the Caribbean has included in its current draft a provision on access to jus-tice in environmental matters (Article 9).
Gabriela Burdiles, Leonardo Cofré
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source