Results 31 to 40 of about 351,517 (296)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Bridging the Mackie–Plantinga Debate on Evil with Ibn Arabi’s Metaphysics
ReligionsThis study examines how Ibn Arabi’s metaphysics can address key challenges in the contemporary philosophical debate on the problem of evil. John Mackie famously argues that the existence of an omnibenevolent and omnipotent God is logically incompatible ...
Elif Nur Balci
doaj +1 more source
Electronic cigarette liquid increases inflammation and virus infection in primary human airway epithelial cells. [PDF]
PLoS ONE, 2014 The use of electronic cigarettes (e-cigarettes) is rapidly increasing in the United States, especially among young people since e-cigarettes have been perceived as a safer alternative to conventional tobacco cigarettes.
Qun Wu +3 more
doaj +1 more source
In defense of fractional free banking
Mises, 2021 This paper examines the debate between the so-called fractionalists and the reservists within the Austrian School of Economics (1994 – 2005), emphasizing the maturity mismatch problem (2009 – 2019). It focuses on the fundamental arguments: the ontological view on currencies as banks’ products (IOUs) and money, the purchasing power of money, and the ...
openaire +4 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Plantinga and the Logical Problem of Evil [PDF]
حکمت و فلسفه, 2007 The "logical problem of evil" is one kind of the "problem of evil." It is claimed that there is a logical inconsistency between belief in the existence of an omniscient, omnipotent, and wholly good God and belief in the existence of evil. Alvin Plantinga
hasan miandari
doaj +1 more source
How Did Evil Come into the World? A Primordial Free-Will Theodicy
Religions, 2023 James P. Sterba has provided a compelling argument to the effect that given the extent of significant, and indeed even horrendous, evil that an all-good and all-powerful being could have prevented, there is no God.
Mark Johnston
doaj +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source