Results 91 to 100 of about 2,038,816 (256)

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Assessing Climate Change Effects on Freeze-Thaw Exposure of Concrete Structures

Nordic Concrete Research
This study presents a novel method to assess the freeze-thaw exposure of concrete structures. The new Relative Freeze-Thaw Exposure index (RFE) is based on regression model that considers location-related actual freeze-thaw damage observations, number of
Pakkala Toni, Lindman Niko, Lahdensivu Jukka   +2 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Impact of soil freeze-thaw mechanism on the runoff dynamics of two Tibetan rivers

, 2019
This dataset is for the paper published in Journal of Hydrology: Zheng, D., van der Velde, R., Su, Z., Wen, J., Wang, X., Yang, K., 2018a. Impact of soil freeze-thaw mechanism on the runoff dynamics of two Tibetan rivers. J. Hydrol.
Zheng, Dr. D (Faculty Of Geo-Information Science and Earth Observation, ITC, University of Twente), Researcher
core   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Constitutive model of fractured rock under coupled freeze-thaw and load based on localized progressive damage effect

Meitan xuebao
Due to the coupling effect of freeze-thaw cycle and external load, it is more difficult to characterize the constitutive relationship of fractured rocks in the cold region under the influence of the progressive propagation of the cluster of primary and ...
Yanhai ZHAO, Yanyu WANG, Qiang CUI, Kai ZHAO   +3 more
doaj   +1 more source

IDENTIFIKASI PIGMEN FIKOBILIPROTEIN PADA KAPPAPHYCUS ALVAREZII DALAM PELARUT BUFFER FOSFAT DENGAN METODE FREEZE THAW CYCLE [PDF]

, 2019
Pendahuluan: Kappaphycus alvarezii mengandung pigmen fikobiliprotein yang terdiri dari fikoeritrin, fikosianin, dan alofikosianin. Pigmen tersebut telah banyak dimanfaatkan dalam bidang kesehatan, seperti sebagai fotosensitiser pada terapi kanker ...
Mayasari, Noor Rohmah, Karseno, Karseno, Setyawati, Retno   +2 more
core   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Dynamic characteristics and damage model of freezing thawing red sandstone under impact load

Meitan xuebao
To study the dynamic mechanical properties and damage evolution characteristics of freeze-thaw rocks under impact loads, 0, 15, 30, 45, and 60 freeze-thaw cycle tests and dynamic impact tests were conducted on red sandstone in cold regions.
Yang YU, Qincai JIANG, Zehua WANG, Yuyin LU, Qixiang GUO, Huiming ZENG   +5 more
doaj   +1 more source