Results 71 to 80 of about 2,038,816 (256)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Freeze-Thaw Dewatering and Structural Enhancement of Fine Coal Tails
, 1995 : An 18.2-ha coal tailings impoundment that reached full capacity in 1989 has since been undergoing reclamation activities. The impoundment is sectioned into coarse, intermediate, and fine tails regions. The fine tails region, which consists of saturated
Stahl, R. P., Sego, D. C.
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Water absorption and chloride diffusivity of concrete under the coupling effect of uniaxial compressive load and freeze-thaw cycles [PDF]
, 2019 In cold coastal area, the destruction mechanism of reinforced concrete structures is mainly governed by a combination of factors such as self-loading, freeze-thaw and chloride erosion. In this study, ordinary cube concretes (C30 and C50, while w/c = 0.53
Zhang, Zuhua +6 more
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Scientific ReportsIn this research, the microstructural damage and the degradation law are investigated for the rock mass in open-pit mine slopes with freeze–thaw cycles.
Yibin Zhang, Yihai Zhang, Xutong Jiang
doaj +1 more source
Freeze-Thaw Cycle Experimental Data
Data on soil physical and structural property indicators following freeze-thaw cycle ...
王, 碧辉
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Evaluation of Fly Ash in Water Reduced Paving Mixtures;MLR-84-07, June 1985 [PDF]
, 1985 Fly ash was used to replace 15% of the cement in C3WR and C6WR concrete paving mixes containing ASTM C494 Type A water reducin9 admixtures. Two Class C ashes and one Class F ash from Iowa approved sources were examined in each mix.
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