Results 41 to 50 of about 149,641 (311)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

In vitro evaluation of spray and freeze-dried bovine colostrum powder and their effects on the nutritional and functional properties

International Journal of Food Properties
Bovine colostrum is the initial milk produced after birth that contains high levels of immunoglobulins and antimicrobial peptides. This study examined the production of bovine colostrum powder using two methods including spray- and freeze-drying.
Muqaddas Fatima, Marina Sajid, Hafiza Saima, Muhammad Tahir Nadeem, Rabia Shabir Ahmad, Sajid Mehmood, Muhammad Zubair Khalid, Sulaiman Ali Alharbi, Mohammad Javed Ansari, Emery Lenge Mukonzo Kasongo   +9 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Effects of Different Drying Methods on Physicochemical Properties and Nutritional Quality of Abalone Bioactive Peptides

Molecules
This study conducted a systematic comparison of four drying methods (vacuum freeze-drying, spray drying, spray freeze-drying, and hot air drying) on abalone bioactive peptides, investigating their effects on physicochemical properties and nutritional ...
Qiting Li, Longxiang Li, Pufu Lai, Yingying Wei, Chunmei Lai, Yusha Liu, Mengjie Yang, Shaoxiong Zhou, Junchen Chen, Junzheng Sun   +9 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Drying technologies for messenger RNA and other nucleic acid-lipid nanoparticles: advances in freeze-drying and beyond

AAPS Open
Nucleic acid therapeutics have emerged as the third major class of therapeutics, following small molecules and antibodies. Lipid nanoparticles (LNPs) serve as the leading platform for nucleic acid delivery.
Zixuan Zhen, Mittal Darji, Xinhao Lin, Robin H. Bogner, Xiuling Lu   +4 more
doaj   +1 more source

Physicochemical, bioactive compounds and antioxidant activities of sweet red corn under different drying methods

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2023
This study investigated the physicochemical properties, bioactive compounds, and antioxidant activities of sweet red corn under different drying methods.
Onanong PHUSEERIT, Theeraphan CHUMROENPHAT   +1 more
doaj   +1 more source

Pengeringan Beku Vakum Bengkuang dengan Memanfaatkan Panas Buang Kondensor untuk Proses Sublimasi [PDF]

, 2014
Vacuum Freeze Drying is one of the best ways of drying products as freeze drying vacuum drying or preserving materials without a change in physical and chemical properties of materials. This study was a continuation of previous studies that
Brama, J. (Jaka), Martin, A. (Awaludin)
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effect of Different Drying Methods on the Quality and Nonvolatile Flavor Components of Oudemansiella raphanipes

Foods, 2023
Different drying methods affect the quality of foods. The aim of this study is to explore the effects of seven drying methods, including hot air drying at 60 °C and 80 °C, ultrasound-assisted hot air drying at 60 °C and 80 °C, microwave drying, vacuum ...
Qiulian Shen, Zedong He, Yangyue Ding, Liping Sun   +3 more
doaj   +1 more source