Results 91 to 100 of about 2,038,939 (300)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Freeze-Thaw Cycle Experimental Data
Data on soil physical and structural property indicators following freeze-thaw cycle ...
王, 碧辉
core +1 more source
Slip‐resistant connections subjected to freeze‐thaw cycles
Steel ConstructionAbstractThere are many examples of steel structures subjected to severe environmental conditions with bolted connections directly exposed to climatic agents such as steel bridges, mining transfer towers, wind towers etc. In this experimental research, non‐slip joints with M16 and M20 bolts have been studied.
Alfonso Fuente‐García +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Evaluation of Fly Ash in Water Reduced Paving Mixtures;MLR-84-07, June 1985 [PDF]
, 1985 Fly ash was used to replace 15% of the cement in C3WR and C6WR concrete paving mixes containing ASTM C494 Type A water reducin9 admixtures. Two Class C ashes and one Class F ash from Iowa approved sources were examined in each mix.
core
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Analysis of Harbin’s Freeze-Thaw Action for Life-Cycle Structure Design
, 2011 To get environmental action information for structural life cycle design and durability design, the air temperature of Harbin (China) from 1963 to 2002 was employed to analyze the probability distribution of freeze-thaw action herein.
Chi Lin, Jin Ping Ou
core +1 more source
Research on damage and degradation of coal-bearing sandstone under freeze-thaw cycles
Frontiers in Earth ScienceComprehending the effect of freeze-thaw cycles on the damage and degradation of coal-bearing sandstones is crucial for the end-wall slope stability of open-pit mines in cold areas.
Yiwen Mao +4 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source