Results 81 to 90 of about 2,038,939 (300)

Strength and Microscopic Damage Mechanism of Yellow Sandstone with Holes under Freezing and Thawing

Advances in Civil Engineering, 2020
In order to study the damage characteristics of the yellow sandstone containing pores under the freeze-thaw cycle, the uniaxial compression test of saturated water-stained yellow sandstones with different freeze-thaw cycles was carried out by rock servo ...
Huren Rong, Jingyu Gu, Miren Rong, Hong Liu, Jiayao Zhang, Hao Dong   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Hero tags protect Fluc activity from freeze-thaw cycles.

, 2022
(A) Schematic representation of the freeze-thaw cycles. (B) Freeze-thaw cycles of Fluc-WT. Fractions of remaining Fluc activities after the second cycle were calculated. Mean ± SD from 5 independent experiments are shown.
Eri Morimoto (12890115), Kotaro Tsuboyama (8565765), Yukihide Tomari (9413)   +2 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Freeze-Thaw Dewatering and Structural Enhancement of Fine Coal Tails

, 1995
: An 18.2-ha coal tailings impoundment that reached full capacity in 1989 has since been undergoing reclamation activities. The impoundment is sectioned into coarse, intermediate, and fine tails regions. The fine tails region, which consists of saturated
Stahl, R. P., Sego, D. C.
core   +1 more source

Water absorption and chloride diffusivity of concrete under the coupling effect of uniaxial compressive load and freeze-thaw cycles [PDF]

, 2019
In cold coastal area, the destruction mechanism of reinforced concrete structures is mainly governed by a combination of factors such as self-loading, freeze-thaw and chloride erosion. In this study, ordinary cube concretes (C30 and C50, while w/c = 0.53
Zhang, Zuhua, Zhang, Peng, Cao, Yubin, Zhao, Tiejun, Ma, Yuwei, Wang, Yanru, Wang, Hao   +6 more
core   +1 more source

The critical freeze-thaw cycle considering moisture content increase in the accelerated freeze-thaw test

Journal of Asian Concrete Federation, 2019
In the paper, specimens with 2 kinds of water to cement ratios were conducted with the accel- erated freeze-thaw test and the critical degree of saturation test. In the accelerated freeze-thaw test, the trend of the relative dynamic modulus of elasticity (RDM) can be divided into two parts.
Dequn Ma, Osamu Senbu, Ryoma Kitagaki
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Study of the degradation and microstructural characteristics of granite porphyry with freeze–thaw cycles

Scientific Reports
In this research, the microstructural damage and the degradation law are investigated for the rock mass in open-pit mine slopes with freeze–thaw cycles.
Yibin Zhang, Yihai Zhang, Xutong Jiang
doaj   +1 more source