Results 81 to 90 of about 915,660 (303)

The critical freeze-thaw cycle considering moisture content increase in the accelerated freeze-thaw test

Journal of Asian Concrete Federation, 2019
In the paper, specimens with 2 kinds of water to cement ratios were conducted with the accel- erated freeze-thaw test and the critical degree of saturation test. In the accelerated freeze-thaw test, the trend of the relative dynamic modulus of elasticity (RDM) can be divided into two parts.
Dequn Ma, Osamu Senbu, Ryoma Kitagaki
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Mechanical Properties and Mesostructure Evolution of Fibre-Reinforced Loess under Freeze-Thaw Cycles

Advances in Civil Engineering, 2023
The strength of loess in seasonal frozen soil areas decreases evidently due to the freeze-thaw cycle, which even leads to some engineering and geological problems.
Longfei Zhang, Zaiqiang Hu, Hongru Li, Haicheng She, Xiaoliang Wang, Xiaoning Han, Xi Yang   +6 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Study on the flexural behaviors of rc beams after Freeze-Thaw cycles

, 2015
order to investigate the flexural behaviors of RC beams after freeze-thaw cycles, compressive strength test of concrete cubes after 0, 50, 100, 125 freeze-thaw cycles were made, and static flexural experiment of 48 RC beams after 0, 50, 100, 125 freeze ...
Ge, Wenjie,, Wang, B.Y.,, Cao, Dafu,, Tu, Yongming,   +3 more
core   +1 more source

Experimental Study on Damage and Degradation Mechanism of Biotite Granulite Under Freeze–Thaw Action

Applied Sciences
With the increasing intensity of resource development in alpine regions, numerous geotechnical engineering problems in cold regions have become increasingly prominent.
Bing Liang, Dong Xia
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Study on the Properties of Malan Loess in Lyuliang Area Under Freeze-thaw Cycles

, 2021
Little research has been mode on freezing and thawing landslides in Shanxi, a typical seasonally frozen soil area, but landslides caused by freezing and thawing every year are frequent.
Jianhui LONG, Lingling ZHANG, Xianli XING, Xiaojuan GUO   +3 more
core   +1 more source