Results 71 to 80 of about 915,660 (303)

Changing of mechanical property and bearing capacity of strongly chlorine saline soil under freeze-thaw cycles

Scientific Reports
Freeze-thaw cycles and compactness are two critical factors that significantly affect the engineering properties and safety of building foundations, especially in seasonally frozen regions. This paper investigated the effects of freeze-thaw cycles on the
Shijun Ding, Shaomin Li, Sen Kong, Qiuyang Li, Taohui Yang, Zhibao Nie, Gaowen Zhao   +6 more
doaj   +1 more source

Study on Mechanical Properties and Damage Characteristics of Red Sandstone under Freeze-thaw and Load

Advances in Civil Engineering, 2021
To analyze the effects of freeze-thaw cycles and confining pressure on the mechanical properties of red sandstone, through freeze-thaw cycles and triaxial compression tests, full stress-strain curves of different freeze-thaw cycles and different ...
Lei Shi, Yang Liu, Xiangzhen Meng, Huimei Zhang   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Compressive behavior of circular concrete-filled steel tubular columns under freeze-thaw cycles [PDF]

, 2020
In this paper, the compressive behavior of circular concrete-filled steel tubular stub columns under freeze-thaw cycles was studied. Influence of different concrete grades and number of freeze-thaw cycles were investigated through experimental study ...
Fu, F., Gao, S., Guo, L., Wang, Y., Peng, Z.   +4 more
core   +1 more source

The freeze-thaw weakening of rock structural planes on slope stability: effects of cycle numbers and burial depth

Geomatics, Natural Hazards & Risk
This study investigates rock slopes in cold-region open-pit mines through integrated laboratory experiments and numerical simulations, revealing the freeze‒thaw weakening laws of structural planes and fractured rock masses.
Penghai Zhang, Yuxin Bai, Lingren Meng, Wanni Yan, Jun Hou, Tianhong Yang   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Freeze-thaw stability of oilseed rape oleosome emulsions [PDF]

This work investigated the stability of natural oleosome emulsions on freeze-thawing. Oleosomes were recovered from oilseed rape seeds following an aqueous extraction process using sodium bicarbonate (0.1 M).
Jakobi, R., Adams, G., Bramante, F., Di Bari, V., Gray, David, Billecke, Nils, Adams, Gary, Waschatko, G., Gray, D. A., Bramante, Filippo, Waschatko, Gustav, Beaudoin, F., di Bari, Vincenzo, Beaudoin, Frederic, Billecke, N., Jakobi, Ralf   +15 more
core   +1 more source

Long-Term Performance of Liners Subjected to Freeze-Thaw Cycles

, 2022
The technique of using clay-sand mixtures as liners has been widely used in several geotechnical projects where hydraulic barriers or waste-buffer layers are required. During weather fluctuations and below-zero temperature conditions, these layers can be
Mosleh Al-Shamrani, Ahmed M. Al-Mahbashi, Muawia Dafalla   +2 more
core   +1 more source