Results 111 to 120 of about 234,413 (355)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Frost Resistance Differences of Concrete in Frequent Natural Freeze–Thaw versus Standard Rapid Method

Buildings
In order to find the anti-freezing durability differences between concrete in the frequent natural freeze–thaw conditions in the northwest of Sichuan Province, China, and concrete in the rapid freeze–thaw conditions of the standard rapid method, the ...
Changzhong Deng, Lei Yu, Haoyu Wang, Zhaolei Liu, Dongmei Fan   +4 more
doaj   +1 more source

Meteorological conditions for complete ice cover on Lake Mashu in Hokkaido, Japan using observational data from 1974 to 2021 and prediction of freeze-up date in February, 2021

, 2022
Takao Kameda, Mamoru HACHIYA, Shingo NIDAIRA, Otoji HOSOKAWA   +3 more
openalex   +2 more sources

A Water Distribution System for Cold Regions: The Single Main Recirculation Method: An Historical Review, Field Evaluation, and Suggested Design Procedures [PDF]

, 1969
Students and residents of the Arctic are familiar with the many problems peculiar to the geographical area. This monograph will consider an adequate, safe, and reliable water distribution system.
Hartman, Charles W., Murphy, R. Sage
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The freeze-tag problem: how to wake up a swarm of robots [PDF]

, 2002
Esther M. Arkin, Michael A. Bender, Sándor P. Fekete, Joseph S. B. Mitchell, Martin Skutella   +4 more
openalex   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Freezing and thawing characteristics of seasonally frozen ground across China

Geoderma
Observations from 1,047 meteorological stations from September 1, 2006 to August 31, 2015 revealed regional differences in the freezing and thawing processes of seasonally frozen ground (SFG) across China.
Xiqiang Wang, Rensheng Chen
doaj   +1 more source

Long-term impact of a bonus freeze on clinical outcome: Analysis of effective and non-effective bonus freezes in cryoballoon ablation.

PLoS ONE, 2019
PurposeData on bonus freeze characteristics and their impact on complication rates and long-term clinical outcome are limited.MethodsPulmonary vein isolation (PVI) using a 28 mm 2nd-generation cryoballoon (CB) was performed in 169 patients (pts).
Buelent Koektuerk, Oezlem Koektuerk, Hikmet Yorgun, Jan-Erik Guelker, Cem Turan, Eduard Gorr, Goekmen Turan, Marc Horlitz, Paul Martin Bansmann   +8 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source