Results 101 to 110 of about 234,413 (355)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Color Stability of Phycoerythrin Crude Extract (PECE) from Rhodomonas Salina Toward Physicochemical Factors

open access: yesSqualen, 2019
Rhodomonas salina produces Cr-phycoerythrin545 as its designated phycoerythrin (PE) with an absorption maximum at 545 nm and a shoulder 564 nm. PE has potential to be applied as colorants, pharmaceutical agents, and fluorescent dye tags. The stability of
Endar Marraskuranto   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Responses of Biennial Sweetclovers of Diverse Latitudinal Adaptation to Various Management Procedures in Alaska [PDF]

open access: yes, 1994
This report summarizes eight experiments with sweetclover (Melilotus species). Objectives were (a) determine responses of numerous cultivars and strains, representing a wide range of latitudinal adaptation, to various management procedures, (b ...
Klebesadel, Leslie J.
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Changes in Arctic Melt Season and Implications for Sea Ice Loss [PDF]

open access: yes
The Arctic-wide melt season has lengthened at a rate of 5 days dec-1 from 1979 to 2013, dominated by later autumn freeze-up within the Kara, Laptev, East Siberian, Chukchi and Beaufort seas between 6 and 11 days dec(exp -1).
Barrett, A.   +4 more
core   +1 more source

UAG R-268 [PDF]

open access: yes, 1979
This study was supported by the Bureau of Land Management through interagency agreement with the National Oceanic and Atmospheric Administration under which a multi-year program responding to need of petroleum development of the Alaskan continental ...
Metzner, Ronald C.   +2 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Modulation of the Kara Sea Ice Variation on the Ice Freeze-Up Time in Lake Qinghai [PDF]

open access: bronze, 2019
Yong Liu   +5 more
openalex   +1 more source

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