Results 81 to 90 of about 234,413 (355)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Modern characteristics of the ice regime of the Lower Yenisei

open access: yesВодное хозяйство России: проблемы, технологии, управление
In the current conditions of climate change, the relevance of the rivers’ ice regime studies is growing. Special features of rivers’ ice regime are a significant component of the transport infrastructure use and, as a consequence, social/economic ...
Vladimir V. Zuev   +2 more
doaj   +1 more source

Bromegrass in Alaska. II. Autumn Food-Reserve Storage, Freeze Tolerance, and Dry-Matter Concentration in Overwintering Tissues as Related to Winter Survival of Latitudinal Ecotypes [PDF]

open access: yes, 1993
The objective of this study was to acquire improved understanding of factors that influence winter survival of bromegrass (Bromus spp.) at northern latitudes.
Klebesadel, Leslie J.
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Freeze-up of Sea Ice

open access: yes, 2010
Typical advance of sea ice over from late summer to late winter is shown on this map. Sea ice is any form of ice that is found at sea and has originated from the freezing of seawater. Formation of sea ice begins in mid-September in the Canadian Arctic and advances southward through the onset of winter. Sea ice begins to form in the St. Lawrence estuary
openaire   +1 more source

Circular 35 [PDF]

open access: yes, 1991
Revised April 1991 by Grant E.M. Matheke, Patricia J. Wagner, and Patricia S. Holloway; Reprinted by Cooperative Extension Service, University of Alaska Fairbanks, and U.S.D.A. Cooperating.
Dinkel, Donald H.   +2 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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