Results 111 to 120 of about 346,153 (317)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Cryoprotective effect of sorbitol on the muscle microstructure of yamú (Brycon amazonicus) during storage at 2 and -18 °C

Revista Facultad Nacional de Agronomía Medellín, 2019
Although freezing is generally used to preserve the sensory and nutritional quality of fish and their products, it cannot mitigate physicochemical changes of the fish meat during storage.
Julián Guillermo León Ramírez, Jairo Humberto López Vargas, José Manuel Lozano Moreno, Adriana Patricia Muñoz Ramirez   +3 more
doaj   +1 more source

Relativistic freeze-in

Physics Letters B, 2019
We study production of scalar dark matter via the freeze--in mechanism in the relativistic regime, focussing on the simplest Higgs portal model. We derive the corresponding relativistic reaction rates based on the Bose--Einstein statistics taking into account the thermal mass effects as well as the change in the Higgs degrees of freedom at the ...
Lebedev, Oleg, Toma, Takashi
openaire   +4 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Intensification of the freeze drying process by the control of both freezing and primary drying steps

, 2013
The problem of optimization of freeze-drying cycles is addressed, with emphasis in both freezing and primary drying steps. In particular, this study shows that the control of the nucleation event produces more uniform batches (as ice nucleation is ...
Barresi, Antonello, Pisano, Roberto, Bullich, R., Oddone, Irene   +3 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency

Molecular Therapy: Nucleic Acids, 2016
The advantages of lipid-based transfection reagents have permitted their widespread use in molecular biology and gene therapy. This study outlines the effect of cryo-manipulation of a cationic lipid-based formulation, Lipofectamine 2000, which, after ...
Helena Sork, Joel Z Nordin, Janne J Turunen, Oscar PB Wiklander, Burcu Bestas, Eman M Zaghloul, Helerin Margus, Kärt Padari, Adil D Duru, Giulia Corso, Jeremy Bost, Pieter Vader, Margus Pooga, CI Edvard Smith, Matthew JA Wood, Raymond M Schiffelers, Mattias Hällbrink, Samir EL Andaloussi   +17 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Freezing the Biological Clock: A Viable Fertility Preservation Option for Young Singaporean Women?

, 2013
In March 2012, an article in The Straits Times entitled ‘Freezing eggs could reverse falling birth rate’ suggested that employing the latest oocyte cryopreservation techniques could both foster individual women’s reproductive autonomy and impact ...
Lee, Geok Ling, Blyth, E., Yee, Samantha, Blyth, Eric, Yee, S., Lee, G.L.   +5 more
core  

Experimental study of the role of physicochemical surface processing on the IN ability of mineral dust particles [PDF]

, 2011
During the measurement campaign FROST 2 (FReezing Of duST 2), the Leipzig Aerosol Cloud Interaction Simulator (LACIS) was used to investigate the influences of various surface modifications on the immersion freezing behavior of Arizona Test Dust (ATD ...
A. Kiselev, T. Clauss, Buchholz, A., E. Mikhailov, Stetzer, O., Kiselev, A., Sullivan, Ryan; id_orcid, Shaw, R. A., Bundke, Ulrich, P. J. DeMott, Reimann, Bernd, Mentel, T. F., Kiselev, Alexei, Wex, Heike, Stratmann, Frank, DeMott, P.J., Reitz, P., S. Hartmann, Clauss, T., B. Reimann, Petters, M., Reimann, B., O. Stetzer, P. Reitz, U. Bundke, Sullivan, R., Hartmann, Susan, Mentel, Thomas F., Sierau, Berko, Mikhailov, E., Petters, Markus D., Shaw, R.A., Stetzer, Olaf, DeMott, Paul J., R. C. Sullivan, Shaw, R., DeMott, P., Niedermeier, Dennis, Petters, M.D., R. A. Shaw, Bundke, U., A. Buchholz, Reitz, Paul, F. Stratmann, DeMott, P. J., Hartmann, S., J. Schneider, Petters, M. D., Schneider, Johannes, Wex, H., Shaw, Raymond A., H. Wex, Niedermeier, D., Sullivan, Ryan C., Stratmann, F., Sullivan, R.C., Sullivan, R. C., Mentel, T.F., Schneider, J., B. Sierau, Clauss, Tina, Buchholz, Angela, D. Niedermeier, M. D. Petters, Mentel, T., T. F. Mentel, Mikhailov, Eugene, Sierau, B.   +67 more
core   +1 more source