Advanced Science, EarlyView.This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng +13 more
wiley +1 more source
Genome-wide characterization of LEA gene family reveals a positive role of BnaA.LEA6.a in freezing tolerance in rapeseed (Brassica napus L.). [PDF]
BMC Plant BiolWang W +12 more
europepmc +1 more source
Climate variations and the physiological basis of temperature dependent biogeography: systemic to molecular hierarchies of thermal tolerance in animals [PDF]
, 2002 Pörtner, Hans-Otto
core
Advanced Science, EarlyView.This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed +10 more
wiley +1 more source
Architected Inverse Nacre Hydrogels With High Strength and Crack‐Insensitive Toughness
Advanced Science, EarlyView.Hydrogels hold promise for biomedical and engineering applications, yet their practical use is fundamentally limited by the strength‐toughness trade‐off and poor fatigue resistance. In this study, a bioinspired inverse nacre architecture constructed via a scalable thermo‐calendering process is introduced, which overcomes these classic limitations ...
Haidi Wu +10 more
wiley +1 more source
Low frequency of the wild-type freezing-tolerance LsCBF7 allele among lettuce population suggests a negative selection during domestication and breeding. [PDF]
Theor Appl GenetPark S, Shi A, Mou B.
europepmc +1 more source
A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection
Advanced Science, EarlyView.A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang +8 more
wiley +1 more source
Workshop report on: Collaboration on plant biotechnology between Chile INIA/Univ of Chile and The Netherlands WUR : 'reaching out, reaching up to join forces to solve world food limitations' [PDF]
, 2009 Wageningen International
core +1 more source
Advanced Science, EarlyView.Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong +21 more
wiley +1 more source
Advanced Science, EarlyView.Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong +8 more
wiley +1 more source