Results 61 to 70 of about 2,098,494 (316)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

“Proven patriots”: the French diplomatic corps, 1789-1799

open access: yes, 2011
This study analyzes a hitherto unexamined group, the French diplomatic corps during the Revolution (1789 to 1799), and focuses on the question of loyalty and conscience.
Frey, Linda S., Frey, Marsha L.
core  

LINGUISTICS – CULTUROLOGY – LINGUOCULTUROLOGY – LINGUISTIC AND CULTURAL STUDIES

open access: yesКонцепт: философия, религия, культура, 2019
Linguistic and cultural studies is a section of linguoculturology that considers the characteristics of the country of the language being studied in their linguistic expression, the vector of which is determined by the professional orientation of the ...
L. G. Vedenina
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Translating French into French: The case of Close Encounters of the Third Kind

open access: yesLinguistica Antverpiensia, New Series – Themes in Translation Studies, 2013
This paper deals with the French dubbed version of Steven Spielberg’s 1977 Close Encounters of the Third Kind. The film features a scientist who mainly speaks French and is helped by an interpreter, who often translates simultaneously or consecutively from French into English and vice versa.
openaire   +3 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Superare BICS e CALP nell’offerta formativa linguistica universitaria in Italia

open access: yesLinguae &: Rivista di Lingue e Culture Moderne, 2019
Contemporary language teaching for educational paths in binational degrees in Engineering is subject to some challenges. In particular the organisation and the graduality of linguistic teaching, according to the traditional subdivision in language for ...
Giovanni Favata, Paolo Nitti
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Arles du xve au xvie siècle, entre latin, provençal et français : deux siècles d’histoire, trois langues en contact

open access: yesRevue des Langues Romanes, 2019
The city of Arles, for many reasons, soon became accustomed to writing evidence of relations with the different powers that governed it. Since the thirteenth century, the Counts of Anjou have succeeded each other at the head of Provence and Arles was ...
Marie Rose Bonnet
doaj   +1 more source

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