Results 61 to 70 of about 2,519,774 (307)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2012 French Cycling: a Social and Cultural History aims to provide a balanced and detailed analytical survey of the complex leisure activity, sport, and industry that is cycling in France.
Dauncey, Hugh
core +2 more sources
LINGUISTICS – CULTUROLOGY – LINGUOCULTUROLOGY – LINGUISTIC AND CULTURAL STUDIES
Концепт: философия, религия, культура, 2019 Linguistic and cultural studies is a section of linguoculturology that considers the characteristics of the country of the language being studied in their linguistic expression, the vector of which is determined by the professional orientation of the ...
L. G. Vedenina
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Étude contrastive des phrases OSV en chinois et en français : application didactique [PDF]
SHS Web of ConferencesThis article presents a contrastive study of the Object– Subject–Verb (OSV) sentence structure in French—specifically, left-dislocated object constructions—and in Chinese, where it corresponds to subject–predicate topicalization constructions.
Ding Xudong, Huang Sa
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Funkční přípustkové konstrukce v češtině a francouzštině: kontrastivní korpusová studie [PDF]
Časopis pro Moderní FilologiiThis paper investigates concessive constructions in Czech and French, focusing on so-called functional concessives—expressions where concessive meaning arises not from explicit grammatical markers but from semantic-pragmatic configurations.
Ondřej Drobník
doaj +1 more source
Translating Contemporary French Poetry [PDF]
, 2018 This article examines a bilingual anthology edited by the authors and published in 2016. It argues that the process of editing an anthology of contemporary poetry with multiple translators is a form of re-writing that not only introduces new writers into
Parish, Nina +2 more
core +1 more source