Results 111 to 120 of about 1,269,200 (229)

A Tumor‐Boundary Niche Enriched for PD‐1+CD8+T Cells and BTLA+B Cells Drives Resistance to Immunotherapy in NSCLC

open access: yesAdvanced Science, EarlyView.
A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu   +6 more
wiley   +1 more source

Engaging Reluctant Readers in a French Immersion Classroom

open access: yesCurrent Issues in Education, 2017
Reading engagement is like a puzzle consisting of many pieces to emplace for successful engagement to occur. The author, a French Immersion teacher/researcher, found that many of her grade one reluctant readers—those students who could read but chose not
Amanda Borton Capina, Gregory Bryan
doaj  

Strengthening Constitutive Motifs in Isotropic Fibrous Hydrogel for Exceptional Damage Resistance

open access: yesAdvanced Science, EarlyView.
An orientation‐free strategy is reported for fabricating damage‐resistant hydrogels by strengthening constitutive motifs in isotropic fibrous (IF) networks. Through nonsolvent quenching followed by salting‐out, IF networks are generated and their multiscale constituents are subsequently reinforced, yielding dense and crystalline isotropic nanofiber ...
Bolin Wan, Xule Yang, Liju Xu, Dong Qiu
wiley   +1 more source

Un outil pour la réussite académique des étudiants en exil : réflexions sur l’amélioration d’un portfolio pour l’immersion universitaire

open access: yesLidil
In this article, we analyse, with a portfolio, a university immersion programme designed for students in exile. The approach adopted is holistic (like the framework of French for Academic Purposes) and tailored to learners with diverse backgrounds.
Donatienne Woerly   +2 more
doaj  

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

open access: yesAdvanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu   +13 more
wiley   +1 more source

Learning disabilities and French immersion : are they compatable?

open access: yes, 2002
Paper 1. A review of the literature on current research in learning disabilities and French immersion. -- Paper 2. The nature and characteristics of learning disabilities: Implications for French immersion placement. -- Paper 3.
Eaton, Nancy
core   +1 more source

Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors

open access: yesAdvanced Science, EarlyView.
Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici   +4 more
wiley   +1 more source

Vision science and the visual arts: an enquiry into the science of perception and the art of immersion [PDF]

open access: yes
This research addresses questions surrounding two currently prominent visual art topics. The first revolves around the concept of immersion and perceptions of immersive art, the second concerns current interests in art and science and the practice of art
Nolan, Lucille Marie
core  

Electrical Properties and Interfacial Strain in Thermally Oxidized 4H‐SiC MOS Structures Under Different Post‐Oxidation Annealing

open access: yesAdvanced Electronic Materials, EarlyView.
This work investigates the electrical properties and interfacial strain in thermally oxidized 4H‐SiC MOS structures under different post‐oxidation annealing. Nitrogen annealing simultaneously reduces interface state density and increases interfacial tensile strain, thus being accompanied by the formation of an interfacial dipole.
Fabrizio Roccaforte   +9 more
wiley   +1 more source

A Conserved Isoleucine Gates the Diffusion of CO and O2 to the Active Site of NiFe CO‐Dehydrogenase

open access: yesAngewandte Chemie, EarlyView.
A combination of protein film electrochemistry and site‐directed mutagenesis shows that isoleucine 563 (numbering of Thermococcus sp. AM4) gates the arrival of both CO and O2 to the active site of the nickel‐iron CO dehydrogenases. Mutations at this position increase the resistance to O2 at the cost of a slower reaction with CO.
Laura Opdam   +7 more
wiley   +2 more sources

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