Results 261 to 270 of about 5,871,149 (318)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Superefficient optical frequency division referenced to μHz Schawlow-Townes-linewidth quantum noise-limited lasers. [PDF]

Sci Adv
Hu J, Xiao Y, Yang H, Xue S, Dong W, Zhai K, Zhu S, Qiu K, Zhang S, Ge J, Zhu NH, Jiang X, Xu J, Wen H, Zhou H.   +14 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Subjective menopausal hot flashes in sleep disturbance: does the timing of hot flashes matter? [PDF]

Menopause
Law C, Gunthert K, Sokolovsky AW, Behar E.   +3 more
europepmc   +1 more source

Schumann-anchored golden ratio organization of human neural oscillations. [PDF]

Front Comput Neurosci
Lacy M.
europepmc   +1 more source

Modal Superposition-Induced Novel Directional Responses in a Low-Damping Biomimetic Microphone for Sound Source Localization. [PDF]

Sensors (Basel)
Ren D, Yang X, Qi ZM.
europepmc   +1 more source

High-frequency EEG synchronization modes as a stable biometric signature in humans. [PDF]

iScience
Vaezi H, Hossein-Zadeh GA.
europepmc   +1 more source

A curved-beam piezoelectric MEMS resonator featuring multiple temperature plateaus with enhanced stability. [PDF]

Microsyst Nanoeng
Lian Y, Li Y, Chen F, Zheng Z, Zhou J, Liu J, Xu F, Yang J, Chen J, Wang C, Kraft M, Lei KM, Martins RP, Mak PI, Wang Y.   +14 more
europepmc   +1 more source

Transcriptional Bursting in Pluripotent Stem Cells. [PDF]

Biology (Basel)
Lin R, Liu Y, Wu Q.
europepmc   +1 more source