Results 101 to 110 of about 135,779 (266)

Frequency-dependent Batesian mimicry [PDF]

Nature, 2001
D W, Pfennig, W R, Harcombe, K S, Pfennig   +2 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Frequency Dependent Waveshaping.

, 1984
Non linear techniques are used more and more commonly in musical sound synthesis Waveshaping allows to produce periodic sounds, whose spectra depend on the input amplitude, but not on the input frequency, as the process is memory-less.This variation can be achieved only acting on the control parameters.
openaire   +1 more source

A Meta-Contrastive Optimization Framework for Multilabel Bug Dependency Classification

Mathematics
Software maintenance and release management demand proper identification of bug dependencies since priority violations or unresolved dependent issues can often lead to a chain of failures.
Jantima Polpinij, Manasawee Kaenampornpan, Bancha Luaphol   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Frequency-Dependent Mating? [PDF]

Evolution, 1983
openaire   +2 more sources

Strength dependency of frequency–magnitude distribution in earthquakes and implications for stress state criticality

Nature Communications
Earthquake size distribution is characterized by the “b-value” of the power law decay, which exhibits spatiotemporal variations. These variations are sometimes evident before a large earthquake.
Satoshi Matsumoto, Yoshihisa Iio, Shinichi Sakai, Aitaro Kato   +3 more
doaj   +1 more source

Frequency Dependency of the Delta-E Effect and the Sensitivity of Delta-E Effect Magnetic Field Sensors. [PDF]

Sensors (Basel), 2019
Spetzler B, Spetzler B, Golubeva EV, Müller C, McCord J, Faupel F.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source