Results 91 to 100 of about 7,200,285 (346)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Nonstationary excitations in Bose-Einstein condensates under the action of periodically varying scattering length with time dependent frequencies

open access: yes, 2007
We investigate nonstationary excitations in 3D-Bose-Einstein condensates in a spherically symmetric trap potential under the modulation of scattering length with slowly varying frequencies (adiabatic modulation).
Abdullaev   +26 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Parametric Instability in Long Optical Cavities and Suppression by Dynamic Transverse Mode Frequency Modulation [PDF]

open access: yes, 2015
Three mode parametric instability has been predicted in Advanced gravitational wave detectors. Here we present the first observation of this phenomenon in a large scale suspended optical cavity designed to be comparable to those of advanced gravitational
Blair, Carl   +7 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Large-signal theory of the effect of dispersive propagation on the intensity modulation response of semiconductor lasers [PDF]

open access: yes, 2000
We have derived an exact large-signal theory of propagation in a dispersive fiber of an optical wave with sinusoidal amplitude and frequency modulation. This has been applied to the study of large-signal direct-modulation of semiconductor lasers.
Peral, Eva, Yariv, Amnon
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Parametric interactions of optical modes [PDF]

open access: yes, 1966
A formalism for treating interactions between optical modes in the presence of time-varying parameters is developed. The problems of parametric oscillation, frequency conversion, and internal laser modulation are treated, as well as a new class of ...
Yariv, Amnon
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Frequency modulation demodulator threshold extension device [PDF]

open access: yes, 1971
Threshold extension device for improving operating performance of frequency modulatioin demodulators by eliminating click-type noise ...
Conrad, W. M., Loch, F. J.
core   +1 more source

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