Results 71 to 80 of about 69,873 (301)

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Left Ventricular Outflow Tract Geometry as a Predictor of Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation Using the Evolut Series

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Predicting the need for permanent pacemaker implantation (PPM) after transcatheter aortic valve implantation (TAVI) is crucial for procedural planning and patient counseling. Aims To evaluate whether left ventricular outflow tract (LVOT) morphology, specifically a tapered configuration, predicts conduction disturbances requiring PPM
Mahmoud Abdelshafy, Angela McInerney, Ahmed Elmeanawy, Paolo Alberto Del Sole, Max Wagener, Hatem Helal, Mahmoud Abozaid, Ashraf Alamir, Tamer Fouad, Alsayed Almarghany, Briain MacNeill, Osama Soliman, Darren Mylotte, Mohammad Abdelghani   +13 more
wiley   +1 more source

Lipid Profile Differences in HIV‐Infected Populations With Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Systematic Review and Meta‐Analysis

Chronic Diseases and Translational Medicine, EarlyView.
PRISMA study flow diagram. ABSTRACT Introduction Advances in HIV management have transformed HIV into a chronic condition, resulting in improved prognosis and increased survival among people living with HIV (PLWH). Traditional risk factors for metabolic dysfunction‐associated steatotic liver disease (MASLD)—including dyslipidemia—are prevalent in PLWH.
Yovita Hartantri, Sherly Lawrensia, Steven Yulius Usman, Nenny Agustanti, Rudi Wisaksana, Nanny Natalia Mulyani Soetedjo, Bachti Alisjahbana   +6 more
wiley   +1 more source

Use of Estimating Equations for Dosing Antimicrobials in Patients with Acute Kidney Injury Not Receiving Renal Replacement Therapy. [PDF]

, 2018
Acute kidney injury (AKI) can potentially lead to the accumulation of antimicrobial drugs with significant renal clearance. Drug dosing adjustments are commonly made using the Cockcroft-Gault estimate of creatinine clearance (CLcr). The Modified Jelliffe
Awdishu, Linda, Bouchard, Josée, Chertow, Glenn M, Connor, Ana Isabel, Macedo, Etienne, Mehta, Ravindra L   +5 more
core   +2 more sources

Two‐Step Synthesis of a Chiral Fluorinated Alcohol With Silica‐Supported Enzyme RrADH in Batch and Continuous Flow Mode

Chemistry – A European Journal, EarlyView.
A two‐step process was transferred from batch to flow mode for the synthesis of (R)‐2‐fluoro‐1‐phenylethanol as a benchmark, consisting of a decarboxylative fluorination in aqueous media, followed by an enantioselective biocatalytic reduction of the prochiral intermediate with RrADH immobilized on silica supraparticles.
Egzon Cermjani, Greta Nölke, Stefano Di Fiore, Christoph Deckers, Doris Hanselmann, Bettina Herbig, Susanne Wintzheimer, Thomas H. Rehm   +7 more
wiley   +1 more source

Nodal frequency-constrained energy storage planning via hybrid data-model driven methods

iEnergy
Cross-regional high voltage direct current (HVDC) systems bring remarkable renewable power injections to the receiver side of power grids. However, HVDC failures result in large disturbances to receivers and cause critical frequency security problems ...
Jiaxin Wang, Jiawei Zhang, Min Yang, Yating Wang, Ning Zhang   +4 more
doaj   +1 more source

Measurements of Forbush decreases at Mars: both by MSL on ground and by MAVEN in orbit

, 2017
The Radiation Assessment Detector (RAD), on board Mars Science Laboratory's (MSL) Curiosity rover, has been measuring ground level particle fluxes along with the radiation dose rate at the surface of Mars since August 2012. Similar to neutron monitors at
Boettcher, Stephan, Dunn, Patrick, Ehresmann, Bent, Guo, Jingnan, Halekas, Jasper, Hassler, Donald M., Larson, Davin, Lee, Christina O., Lillis, Robert, Lundt, Niklas, Papaioannou, Athanasios, Posner, Arik, Rahmati, Ali, Simonson, Patrick, Wimmer-Schweingruber, Robert F., Zeitlin, Cary   +15 more
core   +1 more source

Clinical assessment of mocravimod as a victim of drug–drug interactions via CYP3A4 metabolism and transporters

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Mocravimod, a novel immunomodulator targeting sphingosine‐1‐phosphate receptor (S1PR), is being developed as a maintenance treatment for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. Preclinical data suggested that cytochrome (CYP) 3A4 is the primary enzyme involved in mocravimod metabolism.
Dymphy R. Huntjens, Stephan Oehen, Elisabeth Kueenburg   +2 more
wiley   +1 more source

Analytical Frequency Security Indicators for Two-Region Interconnected Power Systems

IEEE Access
Frequency spatial distribution characteristics of interconnected power systems are highlighted, resulting in significant regional frequency differences and inter-region tie-line power fluctuations, posing a threat to frequency security operation. For two-
Qiang Zhang, Xinwei Li, Guorong Lan, Xiangxu Wang, Jiakai Shen, Hui Zeng, Peng Yuan, Xiaoheng Zhang, Weidong Li   +8 more
doaj   +1 more source

Airborne lidar observations supporting the ADM-Aeolus mission for global wind profiling [PDF]

, 2012
The Atmospheric Dynamics Mission ADM-Aeolus of ESA will be the first lidar mission to sense the global wind field from space. The instrument is based on a direct-detection Doppler lidar operating at 354.9 nm with two spectrometers for aerosol/cloud ...
Lemmerz, Christian, Marksteiner, Uwe, Rahm, Stephan, Reitebuch, Oliver, Witschas, Benjamin   +4 more
core