Results 91 to 100 of about 1,293,707 (300)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Frequency responses of autoregressive models.

open access: yes, 2016
Frequency responses of 20 AR models (1st to 20th order) of one segment of 4 s (green lines). The DFs were determined according to five criteria: 1) High Amp: the DF corresponds to the frequency of the highest peak among all frequency responses (yellow ...
Octavio Martinez Manzanera (2816650)   +3 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Analysis of Natural Scene Derived Spatial Frequency Responses for Estimating Camera ISO12233 Slanted-edge Performance

open access: yes, 2021
The Natural Scene derived Spatial Frequency Response (NS-SFR) framework automatically extracts suitable step-edges from natural pictorial scenes and processes these edges via the edge-based ISO12233 (e-SFR) algorithm.
Jenkin, Robin B.   +3 more
core   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Dissociated behavior of low-frequency responses and high-frequency oscillations after systemic morphine administration in conscious rats

open access: yes, 2010
It has been proposed that high-frequency oscillations (HFOs) and underlying conventional somatosensory-evoked potentials (SEPs) have different brain origins.
Li, Guo-Liang   +7 more
core   +1 more source

Real-time synthesis of the dynamic responses of floating bodies to waves for maritime simulators

open access: yesApplied Ocean Research
A new implementation of the Fourier approach to synthesize spectral waves in real-time was recently published by the authors, based on an efficient GPU implementation and on a very flexible definition of the wave inputs.
Luca Donatini   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

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