Results 41 to 50 of about 4,923,004 (280)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Capacity of Time-Hopping PPM and PAM UWB Multiple Access Communications over Indoor Fading Channels
EURASIP Journal on Wireless Communications and Networking, 2008 The capacity of time-hopping pulse position modulation (PPM) and pulse amplitude modulation (PAM) for an ultra-wideband (UWB) communication system is investigated based on the multipath fading statistics of UWB indoor wireless channels.
T. Aaron Gulliver, Hao Zhang
doaj +2 more sources
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Robust Frequency-Hopping System for Channels with Interference and Frequency-Selective Fading [PDF]
2007 IEEE International Conference on Communications, 2007 A robust frequency-hopping system with noncoherent detection, iterative turbo decoding and demodulation, and channel estimation is presented. The data modulation is the spectrally compact nonorthogonal continuous-phase frequency-shift keying, which strengthens the frequency-hopping system against multiple- access interference and multitone jamming.
Don J. Torrieri +2 more
openaire +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Simulation and measurement of multi-carrier and single-carrier frequency domain equalization systems
Tongxin xuebao, 2009 Chinese national standard of digital terrestrial Television broadcasting（DTTB） was a block transmission system in which the orthogonal frequency-division multiplexing（OFDM） and single-carrier frequency domain equalization（SC-FDE） transmission ...
GAO Zhen1, PENG Ke-wu2, PAN Chang-yong2
doaj +2 more sources
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source