Results 91 to 100 of about 1,968,691 (295)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Coal-rock interface recognition based on terahertz time-domain spectroscopy

Gong-kuang zidonghua, 2017
In order to study feasibility of coal-rock interface recognition based on terahertz time-domain spectroscopy, some experiments were taken out by using terahertz time-domain spectroscopy, which used gas coal and sandstone powder tablet as samples.
WANG Xin, HU Kexiang, YU Xiao, DING Enjie   +3 more
doaj   +1 more source

A stochastic approach for deriving effective linear properties of bilinear hysteretic systems subject to design spectrum compatible strong ground motions [PDF]

, 2011
A novel statistical linearization based approach is proposed to derive effective linear properties (ELPs), namely damping ratio and natural frequency, for bilinear hysteretic oscillators subject to seismic excitations specified by an elastic response ...
Giaralis, A., Kougioumtzoglou, I., Spanos, P. D.   +2 more
core  

A BRITE view on the massive O-type supergiant V973 Scorpii: Hints towards internal gravity waves or subsurface convection zones

, 2018
Stochastically-triggered photospheric light variations reaching $\sim$$40$ mmag peak-to-valley amplitudes have been detected in the O8Iaf supergiant V973 Scorpii as the outcome of two months of high-precision time-resolved photometric observations with ...
Handler, Gerald, Kuschnig, Rainer, Moffat, Anthony F. J., Pigulski, Andrzej, Popowicz, Adam, Ramiaramanantsoa, Tahina, Ratnasingam, Rathish, Rogers, Tamara M., Shenar, Tomer, Wade, Gregg A., Weiss, Werner W., Zwintz, Konstanze   +11 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

PARAMETERS ESTIMATION ALGORITM OF SPREAD SPECTRUM SIGNAL ON LIMITED DATA LENGTH

Научный вестник МГТУ ГА, 2016
This article deals with the algoritm of frequency estimation of a spread spectrum signals based on the parametric method of spectrum analysis which allows to improve accuracy of frequency estimation by multiple repetition of the calculation procedure of ...
B. I. Shakhtarin, Yu. A. Sidorkina, A. A. Nikiforov   +2 more
doaj  

Dielectric behavior of oblate spheroidal particles: Application to erythrocytes suspensions

, 2002
We have investigated the effect of particle shape on the eletrorotation (ER) spectrum of living cells suspensions. In particular, we consider coated oblate spheroidal particles and present a theoretical study of ER based on the spectral representation ...
Huang, J. P., Yu, K. W.
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source