Results 131 to 140 of about 186,401 (311)

Excited state spatial distributions in a cold strontium gas [PDF]

, 2012
This thesis describes the development of a new technique for measuring the spatial distribution of Rydberg atoms in a cold strontium gas. Strontium atoms are cooled and trapped in a magneto-optical trap and coherently excited to Rydberg states in a two ...
LOCHEAD, GRAHAM
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Supersonic combustion instability in a hydrogen-fueled strut-based scramjet combustor

Kongqi donglixue xuebao
Combustion instability is a critical issue limiting the performance and reliability of hypersonic propulsion systems. In this study, Large Eddy Simulation (LES), Fast Fourier Transform (FFT), and Dynamic Mode Decomposition (DMD) were employed to ...
Xiaofei Niu, Qian Chen
doaj   +1 more source

Frequency Stabilization of Nanomechanical Resonators Using Thermally Invariant Strain Engineering. [PDF]

Nano Lett, 2020
Wang M, Zhang R, Ilic R, Aksyuk V, Liu Y.   +4 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Frequency stabilization for mobile satellite terminals via LORAN

, 1990
Digital satellite communication systems require careful management of frequency stability. Historically, frequency stability has been accomplished by continuously powered, high cost, high performance reference oscillators.
Ernst, Gregory J., Kee, Steven M., Marquart, Robert C.   +2 more
core  

Direct Kerr-frequency-comb atomic spectroscopy

, 2018
Microresonator-based soliton frequency combs - microcombs - have recently emerged to offer low-noise, photonic-chip sources for optical measurements.
Jordan R. Stone (3963479), Zachary Newman (6613949), Kerry Vahala (7146992), Myoung-Gyun Suh (12736199), Songbai Kang (4961203), Daniel C. Cole (3961250), John Kitching (14387631), Scott A Diddams (17496510), Connor Fredrick (4961206), Liron Stern (1491877), Scott B. Papp (3961244)   +10 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Delay-line stabilized microwave oscillator with frequency control

, 1997
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The technique whereby the frequency of an oscillator is stabilized using an external feedback network incorporating a delay-line is extended in this thesis ...
Free, Charles Edward
core