Results 91 to 100 of about 504,450 (266)

Fresh Properties and Sulfuric Acid Resistance of Sustainable Mortar Using Alkali-Activated GGBS/Fly Ash Binder. [PDF]

Polymers (Basel), 2022
Mohamed OA, Al Khattab R.
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A Study on the Relationships between Water Film Thickness, Fresh Properties, and Mechanical Properties of Cement Paste Containing Superfine Basalt Powder (SB). [PDF]

Materials (Basel), 2021
Liu H, Tian Z, Fan H.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Optimisation of 3D Printable Cement- and Lime-Based Mortars for Built Heritage Rehabilitation

Buildings
Three-dimensional printing (3DP) represents a significant innovation in the construction sector, offering substantial benefits in terms of efficiency, customisation, and sustainability.
Manuel Jesus, Ricardo Dias, João Teixeira, João M. P. Q. Delgado, Jorge Lino Alves, Bárbara Rangel, Ana Sofia Guimarães   +6 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Properties of ultra-high performance geopolymer concrete: influence of silica fume

Frontiers in Materials
As ultra-high-performance geopolymer concrete (UHPGC) emerges as a sustainable alternative to traditional cement-based materials, optimizing its solid precursor formulation is crucial for maximizing its performance.
Haonan Huang, Liu Yang, Kai Pan, Wen Jiang, Yu Chen, Xianghua Hou   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Methodologies to Design Optimum 3D Printable Mortar Mix: A Review

Buildings
Nowadays, 3D printing has revolutionized the construction and building industry, enabling researchers to push the boundaries of creating structural components with this innovative technique. A key factor for the success of this approach lies in selecting
Isabelle Gerges, Faten Abi Farraj, Nicolas Youssef, Emmanuel Antczak, Fadi Hage Chehade   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source