Results 191 to 200 of about 229,738 (330)

PKCϵ-mediated phosphorylation of TRPC3 channel at S712 is essential for its inactivation during inflammatory signaling. [PDF]

Front Immunol
Casas J, Meana C, San-José G, Balsinde J, Balboa MA.   +4 more
europepmc   +1 more source

Real‐Time Visualization of Isoform‐Specific RAF‐KRAS Interactions in Living Cells Using FRET‐BRET Hybrid Biosensors

Advanced Science, EarlyView.
Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go, Dahee Lee, Minji Kim, Kiseok Han, Gyuho Choi, ChanHui Song, Sanghyun Ahn, Yerim Lee, Jinyoung Lee, Yingxiao Wang, Jung‐Soo Suh, Hwayoung Yun, Tae‐Jin Kim   +12 more
wiley   +1 more source

A piperidinyl amide compound enhances Ca²⁺ signaling in cardiomyocytes by increasing activity of Ca²⁺ pump. [PDF]

Biophys Rep (N Y)
Bovo E, Nikolaienko R, Yuen SL, Makarewich CA, Brinkmann M, Thomas DD, Rebbeck RT, Zima AV.   +7 more
europepmc   +1 more source

In vivo FRET–FLIM reveals cell-type-specific protein interactions in Arabidopsis roots

Nature, 2017
Yuchen Long, Yvonne Stahl, S. Weidtkamp‐Peters, M. Postma, Wenkun Zhou, J. Goedhart, M. Sánchez-Pérez, T. Gadella, R. Simon, B. Scheres, Ikram Blilou   +10 more
semanticscholar   +1 more source

Alkylthienyl Side Groups in Conjugated Polymers Enable Localization of π Electron Density and Facilitate Efficient Hole Transfer

Advanced Science, EarlyView.
Resonance Raman spectroscopy is used in combination with other spectroscopic and morphology characterization techniques to unveil the mechanistic origin of the shift in synthetic strategy to alkylthienyl peripheral groups for high‐performing organic photovoltaics.
Hristo Ivov Gonev, Daniel G. Congrave, Junjun Guo, Jose Marin‐Beloqui, Max Allen, David Bacon, Ankita Kumari, Mohammad Saeed Shadabroo, He Zhu, Dibyajyoti Ghosh, Rachel C. Kilbride, Safa Shoaee, Hugo Bronstein, Tracey M. Clarke   +13 more
wiley   +1 more source

Scalable Multiparametric Characterization of Aptamer-Target Interactions. [PDF]

ACS Nano
Sulliger M, Peters M, Sottini A, Stuber A, Yang K, Nakatsuka N, Ortega Arroyo J, Quidant R.   +7 more
europepmc   +1 more source

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

Naphthalimide-Appended Squaraine Rotaxanes Exhibit Enhanced FRET Efficiency. [PDF]

J Phys Chem A
Lau JY, Shaffer CC, Sanders HS, Smith BD.   +3 more
europepmc   +1 more source

Iron/Cobalt Dual‐Atom Catalyst Orchestrate Photothermal‐Chemodynamic Immunotherapy Against MRSA: Multi‐Omics Dissection in Murine and Porcine Models

Advanced Science, EarlyView.
FeCo dual‐atom catalyst (FeCo‐N‐DAC) with ultrahigh metal loading (Fe > 5.4%, Co > 4.8%) is developed for synergistic photothermal‐chemodynamic immunotherapy. FeCo‐N‐DAC penetrates deep‐seated tissues, eradicates MRSA biofilms, and reprograms immune‐inflammatory pathways via multi‐omics‐validated mechanisms.
Shihao Xu, Binge Huang, Hao Lin, Jinming Li, Zhaoxiang Lu, Qi Zhang, Jia Li, Shiping Yang, Songsong Lan, Yan Yang, Yun Feng, Xiaojun He   +11 more
wiley   +1 more source

Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy. [PDF]

Elife
Arifova L, MacTavish BS, Laughlin Z, Karadi Girdhar MN, Shang J, Li MH, Yu X, Zhu D, Kamenecka TM, Kojetin DJ.   +9 more
europepmc   +1 more source