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Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources [PDF]
Molecules, 2021 Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world.
Alfred Ngenge Tamfu +4 more
doaj +5 more sources
Inhibitory Compounds Targeting Plasmodium falciparum Gyrase B. [PDF]
Antimicrob Agents Chemother, 2021 Malaria persists as a major health problem due to the spread of drug resistance and the lack of effective vaccines. DNA gyrase is a well-validated and extremely effective therapeutic target in bacteria, and it is also known to be present in the apicoplast of malarial species, including Plasmodium falciparum .
Pakosz Z +4 more
europepmc +4 more sources
Potent Acetylcholinesterase Inhibitory Compounds from [PDF]
Natural Product Communications, 2014 The anti-cholinesterase activity was evaluated of the ethyl acetate fraction of the methanol extract of Myristica fragrans Houtt (Myristicaceae) seeds and of compounds isolated from it by various chromatographic techniques. The chemical structures of the
To Dao Cuong +9 more
doaj +3 more sources
Anti-gout potential of selected Malaysian local fruits [PDF]
, 2021 This study aimed to investigate the in vitro xanthine oxidase (XO) inhibitory activity and phytochemical content of guava, water rose apple, Malay gooseberry, pineapple and ambarella.
Abu Bakar +22 more
core +1 more source
A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2
Microorganisms, 2021 The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in serious chaos all over the world.
Seri Jo +4 more
doaj +1 more source
Frontiers in Nutrition, 2022 In the recent years, edible brown seaweed, Undaria pinnatifida, has presented beneficial effects, which may be correlated with this species containing major bioactive compounds, such as carotenoids, fatty acids, and phytosterols.
Shipeng Yin +5 more
doaj +1 more source
Structure-activity relationships of fluorene compounds inhibiting HCV variants [PDF]
, 2020 Approximately 71 million people suffer from hepatitis C virus (HCV) infection worldwide. Persistent HCV infection causes liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, resulting in approximately 400,000 deaths ...
Gadhe, Changdev G. +10 more
core +1 more source
Pyridazine Based Compounds with PARP-1 Inhibitory Activity
Archives of Pharmaceutical Sciences Ain Shams University, 2023 Pyridazine-containing compounds have been identified as potent PARP1 inhibitors. The PARP is a family of enzymes essential for many cellular processes such as DNA repair, genomic stability, and apoptosis, also known as poly(ADP-ribose) synthetases and ...
Norhan A. Abdelrahman +3 more
doaj +1 more source
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea [PDF]
, 2015 Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules.
Carolina Bruno De Sousa +14 more
core +7 more sources
Molecules, 2023 A series of (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide derivatives was synthesized and evaluated for inhibitory activity against monoamine oxidase (MAO)-A and-B, acetylcholine esterase (AChE), and butyrylcholine esterase (BChE).
Qing-Hao Jin +6 more
doaj +1 more source