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Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources [PDF]

Molecules, 2021
Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world.
Alfred Ngenge Tamfu, Selcuk Kucukaydin, Balakyz Yeskaliyeva, Mehmet Ozturk, Rodica Mihaela Dinica   +4 more
doaj   +2 more sources

Optimization of fucoxanthin extraction obtained from natural by-products from Undaria pinnatifida stem using supercritical CO2 extraction method

Frontiers in Nutrition, 2022
In the recent years, edible brown seaweed, Undaria pinnatifida, has presented beneficial effects, which may be correlated with this species containing major bioactive compounds, such as carotenoids, fatty acids, and phytosterols.
Shipeng Yin, Shipeng Yin, Liqiong Niu, Mario Shibata, Yuanfa Liu, Tomoaki Hagiwara   +5 more
doaj   +1 more source

A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2

Microorganisms, 2021
The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in serious chaos all over the world.
Seri Jo, Suwon Kim, Jahyun Yoo, Mi-Sun Kim, Dong Hae Shin   +4 more
doaj   +1 more source

Pyridazine Based Compounds with PARP-1 Inhibitory Activity

Archives of Pharmaceutical Sciences Ain Shams University, 2023
Pyridazine-containing compounds have been identified as potent PARP1 inhibitors. The PARP is a family of enzymes essential for many cellular processes such as DNA repair, genomic stability, and apoptosis, also known as poly(ADP-ribose) synthetases and ...
Norhan A. Abdelrahman, Mai Y. Jaballah, Ahmed A. Al-Karmalawy , Khaled A. M. Abouzid   +3 more
doaj   +1 more source

(S)-N-Benzyl-1-phenyl-3,4-dihydroisoqunoline-2(1H)-carboxamide Derivatives, Multi-Target Inhibitors of Monoamine Oxidase and Cholinesterase: Design, Synthesis, and Biological Activity

Molecules, 2023
A series of (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide derivatives was synthesized and evaluated for inhibitory activity against monoamine oxidase (MAO)-A and-B, acetylcholine esterase (AChE), and butyrylcholine esterase (BChE).
Qing-Hao Jin, Li-Ping Zhang, Shan-Shan Zhang, Dai-Na Zhuang, Chu-Yu Zhang, Zhou-Jun Zheng, Li-Ping Guan   +6 more
doaj   +1 more source

Inhibition of SARS-CoV 3CL protease by flavonoids

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required.
Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim   +3 more
doaj   +1 more source

Inhibition of African swine fever virus protease by myricetin and myricitrin

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
African swine fever (ASF) caused by the ASF virus (ASFV) is the most hazardous swine disease. Since a huge number of pigs have been slaughtered to avoid a pandemic spread, intense studies on the disease should be followed quickly. Recent studies reported
Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim   +3 more
doaj   +1 more source

In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential α-glucosidase and α-amylase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
In this paper, bis (indol-3-yl) methanes (BIMs) were synthesised and evaluated for their inhibitory activity against α-glucosidase and α-amylase. All synthesised compounds showed potential α-glucosidase and α-amylase inhibitory activities. Compounds 5 g (
Peng-Fei Zheng, Zhuang Xiong, Cui-ying Liao, Xin Zhang, Mei Feng, Xiao-Zheng Wu, Jing Lin, Lin-Sheng Lei, You-Cheng Zhang, Shao-Hua Wang, Xue-Tao Xu   +10 more
doaj   +1 more source

NADES Compounds Identified in Hypoxis hemerocallidea Corms during Dormancy

Plants, 2022
Soaking Hypoxis hemerocallidea corms in distilled water improved the propagation and development of cormlets, suggesting the potential leaching-out of inhibitory chemical compounds.
Motiki M. Mofokeng, Gerhard Prinsloo, Hintsa T. Araya, Stephen O. Amoo, Christian P. du Plooy, Phatu W. Mashela   +5 more
doaj   +1 more source

Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Coronavirus disease 2019 (COVID-19) has been a pandemic disease of which the termination is not yet predictable. Currently, researches to develop vaccines and treatments is going on globally to cope with this disastrous disease.
Seri Jo, Suwon Kim, Dae Yong Kim, Mi-Sun Kim, Dong Hae Shin   +4 more
doaj   +1 more source