Results 31 to 40 of about 423,721 (164)

Synthesis and Activity Evaluation of Vinpocetine-Derived Indole Alkaloids

Molecules, 2023
This study focuses on the synthesis of novel vinpocetine derivatives (2–25) and their biological evaluation. The chemical structures of the synthesized compounds were fully characterized using techniques such as 1H NMR, 13C NMR, and HRMS.
Zhang-Chao Dong, Yang Shi, Liang-Liang Zheng, You-Ping Tian, Jian Yang, Ying Wei, Ying Zhou, Bo-Wen Pan   +7 more
doaj   +1 more source

Bioassay-Guided Isolation of Anti-Alzheimer Active Components from the Aerial Parts of Hedyotis diffusa and Simultaneous Analysis for Marker Compounds

Molecules, 2020
Previous studies have reported that Hedyotis diffusa Willdenow extract shows various biological activities on cerebropathia, such as neuroprotection and short-term memory enhancement.
Jun Hee Park, Wan Kyunn Whang
doaj   +1 more source

Three New Benzophenone Derivatives from Selaginella tamariscina

Molecules, 2023
Six compounds including three new benzophenones, selagibenzophenones D-F (1–3), two known selaginellins (4–5) and one known flavonoid (6), were isolated from Selaginella tamariscina.
Jiayin Long, Qingqing Mao, Yujie Peng, Lei Liu, Yin Hong, Honglin Xiang, Ming Ma, Hui Zou, Junwei Kuang   +8 more
doaj   +1 more source

Synthesis of chiral pyrazolo[4,3-e][1,2,4]triazine sulfonamides with tyrosinase and urease inhibitory activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A new series of sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazine with chiral amino group has been synthesized and characterized. The compounds were tested for their tyrosinase and urease inhibitory activity.
Mariusz Mojzych, Paweł Tarasiuk, Katarzyna Kotwica-Mojzych, Muhammad Rafiq, Sung-Yum Seo, Michał Nicewicz, Emilia Fornal   +6 more
doaj   +1 more source

Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production

Molecules, 2014
Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae).
Bing-You Yang, Rui Guo, Ting Li, Yan Liu, Chang-Fu Wang, Zun-Peng Shu, Zhi-Bin Wang, Jing Zhang, Yong-Gang Xia, Hai Jiang, Qiu-Hong Wang, Hai-Xue Kuang   +11 more
doaj   +1 more source

Synthesis and Cap-Dependent Endonuclease Inhibition of Baloxavir Derivatives

Crystals, 2023
Baloxavir marboxil is a creative antiviral drug for influenza A and B viruses with a novel mechanism of action. In this study, three series comprising a total of 21 previously unreported target compounds were designed and synthesized.
Yiyun Wang, Jiaru Wang, Hui Wu, Longyao Cui, Zihui Meng, Zhibin Xu, Zhonghui Zheng, Jiarong Li   +7 more
doaj   +1 more source

Pancreatic lipase inhibitory activity of selected pharmaceutical agents

Acta Pharmaceutica, 2019
Twenty-five structurally diverse compounds have been tested in vitro for their pancreatic lipase (PL) inhibitory activity. Despite the diversity of tested compounds, the relationship comprising structural attributes of the compounds could be established ...
Hamdan Imad I., Kasabri Violet N., Al-Hiari Yusuf M., El-Sabawi Dina, Zalloum Hiba   +4 more
doaj   +1 more source

New Indole Alkaloids from the Bark of Rauvolfia Reflexa and their Cholinesterase Inhibitory Activity

Cellular Physiology and Biochemistry, 2015
Background/Aims: Rauvolfia reflexa is a member of the Apocynaceae family. Plants from the Apocynaceae family have been traditionally used in the treatment of age-related brain disorders Methods and Results: Two new indole alkaloids, rauvolfine C (1) and ...
Mehran Fadaeinasab, Alireza Basiri, Yalda Kia, Hamed Karimian, Hapipah Mohd Ali, Vikneswaran Murugaiyah   +5 more
doaj   +1 more source

Synthesis and Cholinesterase Inhibitory Activity of Selected Indole-Based Compounds

Acta Chimica Slovenica, 2023
Synthesis and anticholinesterase activity of 18 previously unpublished indole- and tryptophan-derived compounds are disclosed. These compounds containing an indole structural unit exhibit selective submicromolar inhibition of human butyrylcholinesterase (hBChE).
Gršič, Marija, Meden, Anže, Knez, Damijan, Jukič, Marko, Svete, Jurij, Gobec, Stanislav, Grošelj, Uroš   +6 more
openaire   +4 more sources

Correlation between Growth Inhibitory Exhibition and Suspected Allelochemicals (Phenolic Compounds) in the Extract of Alfalfa (Medicago sativaL.)

Plant Production Science, 2003
Acidic fractions of the extracts from the three alfalfa cultivars Batasu, Rasen, and Yuba exhibited a varietial difference in the inhibitory effect on hypocotyls and radicle growth of alfalfa (cv. Nasuwakaba) and rice (cv. Koshihikari) seedlings.
Tran Dang Xuan, Eiji Tsuzuki, Hiroyuki Terao, Mitsuhiro Matsuo, Tran Dang Khanh   +4 more
doaj   +1 more source